TY - GEN
T1 - On the constraint of gene regulatory networks to canalizing functions and post classes
AU - Pal, Ranadip
AU - Lahdesmaki, Harri
AU - Shmulevich, Ilya
AU - Yli-Harja, Olli
AU - Dougherty, Edward
PY - 2008
Y1 - 2008
N2 - An important preliminary goal in learning biological network models from experimental data is to study the plausibility of different types of regulatory mechanisms in living organisms. In addition to providing important biological insight, the knowledge of abundance of some specific regulatory rules in nature helps the computational problems by restricting the space of possible models to be learned. In this paper, we assess the plausibility of canalizing functions and certain Post (closed) function classes by examining the feasibility of generating networks containing one class at a time that satisfies some predefined network constraints. The results suggest that these two families of regulatory rules are plausible in the light of currently available experimental data.
AB - An important preliminary goal in learning biological network models from experimental data is to study the plausibility of different types of regulatory mechanisms in living organisms. In addition to providing important biological insight, the knowledge of abundance of some specific regulatory rules in nature helps the computational problems by restricting the space of possible models to be learned. In this paper, we assess the plausibility of canalizing functions and certain Post (closed) function classes by examining the feasibility of generating networks containing one class at a time that satisfies some predefined network constraints. The results suggest that these two families of regulatory rules are plausible in the light of currently available experimental data.
UR - http://www.scopus.com/inward/record.url?scp=51549109384&partnerID=8YFLogxK
U2 - 10.1109/GENSIPS.2008.4555672
DO - 10.1109/GENSIPS.2008.4555672
M3 - Conference contribution
AN - SCOPUS:51549109384
SN - 9781424423729
T3 - GENSIPS'08 - 6th IEEE International Workshop on Genomic Signal Processing and Statistics
BT - GENSIPS'08 - 6th IEEE International Workshop on Genomic Signal Processing and Statistics
T2 - 6th IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'08
Y2 - 8 June 2008 through 10 June 2008
ER -