OCT analysis of microneedle and Er:YAG surface ablation for enhanced transdermal delivery of hyper-osmotic agents for optical skin clearing

Oliver Stumpp, A. J. Welch, Harvinder S. Gill, Mark R. Prausnitz

Research output: Contribution to journalConference article

8 Scopus citations

Abstract

The feasability of using microneedles in comparison to Er:YAG skin surface laser ablation was investigated. It was done to modify the epidermis of in-vitro hamster skin to facilitate delivery of topically applied hyper-osmotics for optical skin clearing. This allows to reduce scattering in turbid tissues with potential applications pertaining to non-invasive optical imaging techniques such as optical coherence tomography (OCT). The localized data analysis produced by the techniques yield comparable results that shows an increase in the clearing rate of up to 10 to 13 times over intact skin.

Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5319
DOIs
StatePublished - 2004
EventProgress in Biomedical Optics and Imaging - Laser Interaction with Tissue and Cells XV - San Jose, CA, United States
Duration: Jan 26 2004Jan 28 2004

Keywords

  • Epidermal modification
  • Er:YAG laser ablation
  • Glycerol
  • Microneedles
  • Optical coherence tomography
  • Optical skin clearing
  • Transdermal drug delivery

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