OCT analysis of microneedle and Er:YAG surface ablation for enhanced transdermal delivery of hyper-osmotic agents for optical skin clearing

Oliver Stumpp; A. J. Welch; Harvinder S. Gill; Mark R. Prausnitz

doi:10.1117/12.529504

OCT analysis of microneedle and Er:YAG surface ablation for enhanced transdermal delivery of hyper-osmotic agents for optical skin clearing

Oliver Stumpp, A. J. Welch, Harvinder S. Gill, Mark R. Prausnitz

Chemical Engineering

Research output: Contribution to journal › Conference article › peer-review

8 Scopus citations

Abstract

The feasability of using microneedles in comparison to Er:YAG skin surface laser ablation was investigated. It was done to modify the epidermis of in-vitro hamster skin to facilitate delivery of topically applied hyper-osmotics for optical skin clearing. This allows to reduce scattering in turbid tissues with potential applications pertaining to non-invasive optical imaging techniques such as optical coherence tomography (OCT). The localized data analysis produced by the techniques yield comparable results that shows an increase in the clearing rate of up to 10 to 13 times over intact skin.

Original language	English
Pages (from-to)	121-129
Number of pages	9
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5319
DOIs	https://doi.org/10.1117/12.529504
State	Published - 2004
Event	Progress in Biomedical Optics and Imaging - Laser Interaction with Tissue and Cells XV - San Jose, CA, United States Duration: Jan 26 2004 → Jan 28 2004

Keywords

Epidermal modification
Er:YAG laser ablation
Glycerol
Microneedles
Optical coherence tomography
Optical skin clearing
Transdermal drug delivery

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10.1117/12.529504

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title = "OCT analysis of microneedle and Er:YAG surface ablation for enhanced transdermal delivery of hyper-osmotic agents for optical skin clearing",

abstract = "The feasability of using microneedles in comparison to Er:YAG skin surface laser ablation was investigated. It was done to modify the epidermis of in-vitro hamster skin to facilitate delivery of topically applied hyper-osmotics for optical skin clearing. This allows to reduce scattering in turbid tissues with potential applications pertaining to non-invasive optical imaging techniques such as optical coherence tomography (OCT). The localized data analysis produced by the techniques yield comparable results that shows an increase in the clearing rate of up to 10 to 13 times over intact skin.",

keywords = "Epidermal modification, Er:YAG laser ablation, Glycerol, Microneedles, Optical coherence tomography, Optical skin clearing, Transdermal drug delivery",

author = "Oliver Stumpp and Welch, {A. J.} and Gill, {Harvinder S.} and Prausnitz, {Mark R.}",

year = "2004",

doi = "10.1117/12.529504",

language = "English",

volume = "5319",

pages = "121--129",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

note = "Progress in Biomedical Optics and Imaging - Laser Interaction with Tissue and Cells XV ; Conference date: 26-01-2004 Through 28-01-2004",

}

OCT analysis of microneedle and Er:YAG surface ablation for enhanced transdermal delivery of hyper-osmotic agents for optical skin clearing. / Stumpp, Oliver; Welch, A. J.; Gill, Harvinder S. et al.
In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 5319, 2004, p. 121-129.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - OCT analysis of microneedle and Er:YAG surface ablation for enhanced transdermal delivery of hyper-osmotic agents for optical skin clearing

AU - Stumpp, Oliver

AU - Welch, A. J.

AU - Gill, Harvinder S.

AU - Prausnitz, Mark R.

PY - 2004

Y1 - 2004

N2 - The feasability of using microneedles in comparison to Er:YAG skin surface laser ablation was investigated. It was done to modify the epidermis of in-vitro hamster skin to facilitate delivery of topically applied hyper-osmotics for optical skin clearing. This allows to reduce scattering in turbid tissues with potential applications pertaining to non-invasive optical imaging techniques such as optical coherence tomography (OCT). The localized data analysis produced by the techniques yield comparable results that shows an increase in the clearing rate of up to 10 to 13 times over intact skin.

AB - The feasability of using microneedles in comparison to Er:YAG skin surface laser ablation was investigated. It was done to modify the epidermis of in-vitro hamster skin to facilitate delivery of topically applied hyper-osmotics for optical skin clearing. This allows to reduce scattering in turbid tissues with potential applications pertaining to non-invasive optical imaging techniques such as optical coherence tomography (OCT). The localized data analysis produced by the techniques yield comparable results that shows an increase in the clearing rate of up to 10 to 13 times over intact skin.

KW - Epidermal modification

KW - Er:YAG laser ablation

KW - Glycerol

KW - Microneedles

KW - Optical coherence tomography

KW - Optical skin clearing

KW - Transdermal drug delivery

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U2 - 10.1117/12.529504

DO - 10.1117/12.529504

M3 - Conference article

AN - SCOPUS:5644239750

SN - 0277-786X

VL - 5319

SP - 121

EP - 129

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Progress in Biomedical Optics and Imaging - Laser Interaction with Tissue and Cells XV

Y2 - 26 January 2004 through 28 January 2004

ER -

OCT analysis of microneedle and Er:YAG surface ablation for enhanced transdermal delivery of hyper-osmotic agents for optical skin clearing

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Keywords

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