Nutritional and hormonal regulation of genes encoding enzymes involved in fat synthesis

Hei Sook Sui, Naima Moustaid, Kenji Sakamoto, Cynthia Smas, Nick Gekakis, Ann Jerkins

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Fatty acid and triacylglycerol synthesis for energy storage is known to be regulated in response to the nutritional and hormonal state of the animal-Subjecting rats to a few days of fasting results in the inhibition of lipogenesis; when fasted animals are subsequently fed a diet high in carbohydrate and low in fat, there is a prompt rise in the production of fatty acids and triacylglycerol to levels above those seen in normally fed rats.1, 2 Under these conditions, excess glucose in the cell is first converted to pyruvate via glycolysis. Pyruvate is converted to acetyl CoA which is used for the synthesis of long chain fatty acids, primarily palmitate. NADPH required for fatty acid synthesis is produced by the malic enzyme or via the pentose phosphate pathway. The fatty acids produced are then used for esterification onto glycerol-3-phosphate to generate triacylglycerol. Many key enzymes involved in these metabolic pathways are induced during the refeeding period.1 The increase in the concentration of enzymes, such as of fatty acid synthase, has been shown to be due to the increased synthesis of enzyme protein.3

Original languageEnglish
Title of host publicationNutrition and Gene Expression
PublisherCRC Press
Number of pages20
ISBN (Electronic)9781351083560
ISBN (Print)0849369614, 9781315896014
StatePublished - Jan 1 2018


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