Numerical study of pore density distribution and pore formation energy

Hao Qiu, Xianping Wang, Ravindra Joshi, Wenbing Zhao

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Simulations to quantify the pore density and transmembrane potential due to high-intensity, ultra-short duration electrical pulses have been carried out in the process of electroporation and then pore formation energy is probed by taking account of the strain energy based on the continuum model. Our results demonstrate that pore density would escalate rapidly to higher level though transmembrane potential varies in different membrane surface and the strain energy would lead to pore stability, refraining from pore growth. In addition, calculations show that pore formation energy for one pore system would be higher than that of a two-pore system, and the trend keeps with larger pore radius. It is predicted that the membrane would likely evolve towards high density of multiple pores due to high intensity electric pulses, which is consistent with reports in the literature.

Original languageEnglish
Title of host publicationIMBioc 2018 - 2018 IEEE/MTT-S International Microwave Biomedical Conference
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages202-204
Number of pages3
ISBN (Print)9781538659182
DOIs
StatePublished - Aug 7 2018
Event2018 IEEE/MTT-S International Microwave Biomedical Conference, IMBioc 2018 - Philadelphia, United States
Duration: Jun 14 2018Jun 15 2018

Publication series

NameIMBioc 2018 - 2018 IEEE/MTT-S International Microwave Biomedical Conference

Conference

Conference2018 IEEE/MTT-S International Microwave Biomedical Conference, IMBioc 2018
Country/TerritoryUnited States
CityPhiladelphia
Period06/14/1806/15/18

Keywords

  • Electric pulse
  • Electroporation
  • Pore density
  • Pore energy

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