心衰脉动过程两级轴流血泵溶血数值模拟

Translated title of the contribution: Numerical simulation on hemolysis induced by two-stage axial-flow blood pump during pulsating heart failure

Bingjing Zhou, Guijie Zhang, Teng Jing, Hao Wang, Zhaoming He

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

To understand hemolysis of a blood pump under a pulsatile flow condition, a multi-scale model of the blood pump and cardiovascular circulatory system was built. This multi-scale model consists of a lumped parameter sub-model for the cardiovascular circulation and a three-dimensional distributed parameter sub-model for an axial-flow blood pump. Based on a specific two-stage axial-flow blood pump, the transient outlet pressure and flow rate through the pump were obtained by using the lumped model with Matlab simulation during a cardiac cycle under heart failure conditions. Then, according to the internal hemodynamic characteristics of the blood pump, the transient working condition was divided into a few flow rates, the hemolysis of the pump was predicted based on these flow rates in a quasi-steady manner. Finally, a time-weighted average hemolysis was calculated in one cardiac cycle. The results show that the pump transient pressure difference-flow rate curve is a closed loop in one cardiac cycle due to the inertia of the blood pump. Besides, the hemolysis and pressure difference exhibit a similar variation trend in one cardiac cycle, the flow rate is in an opposite variation trend. In summary, the method of multi-scale model can be used to estimate the hemolysis of a blood pump supporting patient with heart failure.

Translated title of the contributionNumerical simulation on hemolysis induced by two-stage axial-flow blood pump during pulsating heart failure
Original languageChinese
Pages (from-to)28-34
Number of pages7
JournalPaiguan Jixie Gongcheng Xuebao/Journal of Drainage and Irrigation Machinery Engineering
Volume36
Issue number1
DOIs
StatePublished - Jan 28 2018

Keywords

  • Cardiac cycle
  • Heart failure
  • Hemolysis
  • Multi-scale model
  • Two-stage axial-flow blood pump

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