TY - JOUR
T1 - Numerical analysis of two-stage axial blood pump based on blood damage
AU - Zhou, Bingjing
AU - Jing, Teng
AU - Wang, Fangqun
AU - He, Zhaoming
N1 - Publisher Copyright:
© 2016, Editorial Office of Journal of Biomedical Engineering. All right reserved.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - The implantable miniaturized axial blood pump works at a high rotational speed, which increases the risk of blood damage. In this article, we aimed to reduce the possibility of hemolysis and thrombosis by designing a two-stage axial blood pump. Under the operation conditions of flow rate 5 L/min and outlet pressure of 100 mm Hg, we carried out the numerical simulation on the two-stage and single-stage blood pumps to compare the hemolysis and platelet activation state. The results turned out that the hemolysis index of two-stage axial blood pump was better while the platelet activation state was worse than those of single stage design. On the index of hemolysis level and platelet activation state, the design of the two-stage pump with the low and high-head impeller combination was better than the two-stage pump with the equal heads, or the high and low-head impeller combination. In terms of reducing the risk of blood damage for implantable miniaturized axial blood pump, the research result can provide some theoretical basis and new design ideas.
AB - The implantable miniaturized axial blood pump works at a high rotational speed, which increases the risk of blood damage. In this article, we aimed to reduce the possibility of hemolysis and thrombosis by designing a two-stage axial blood pump. Under the operation conditions of flow rate 5 L/min and outlet pressure of 100 mm Hg, we carried out the numerical simulation on the two-stage and single-stage blood pumps to compare the hemolysis and platelet activation state. The results turned out that the hemolysis index of two-stage axial blood pump was better while the platelet activation state was worse than those of single stage design. On the index of hemolysis level and platelet activation state, the design of the two-stage pump with the low and high-head impeller combination was better than the two-stage pump with the equal heads, or the high and low-head impeller combination. In terms of reducing the risk of blood damage for implantable miniaturized axial blood pump, the research result can provide some theoretical basis and new design ideas.
KW - Hemolysis
KW - Numerical simulation
KW - Thrombosis
KW - Two-stage axial blood pump
UR - http://www.scopus.com/inward/record.url?scp=85043549743&partnerID=8YFLogxK
U2 - 10.7507/1001-5515.20160113
DO - 10.7507/1001-5515.20160113
M3 - Article
C2 - 29714907
AN - SCOPUS:85043549743
SN - 1001-5515
VL - 33
SP - 686-690 and 697
JO - Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering
JF - Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering
IS - 4
ER -