TY - JOUR
T1 - Novel insights of dietary polyphenols and obesity.
AU - Wang, Shu
AU - Moustaid-Moussa, Naima
AU - Chen, L
AU - Mo, H
AU - Shastri, Anuradha
AU - Su, R
AU - Bapat, Priyanka
AU - Kwun, I
AU - Shen, C L
N1 - Funding Information:
This work was supported by National Institutes of Health (NIH)/National Center for Complementary and Alternative Medicine (NCCAM) grant ( U01AT006691 ), Laura W. Bush Institute for Women’s Health (C.L.S.), Texas Department of Agriculture Food and Fiber Research Program , Texas Woman's University Research Enhancement Program (H.M.) and National Research Foundation of Korea (NRF, grant no. NRF-2008-220F00013 and NRF-2011-0014535 ) (I.S.K.). The contents of this manuscript are solely the responsibility of the authors and do not necessarily represent the official views of NCCAM or NIH.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The prevalence of obesity has steadily increased over the past three decades both in the United States and worldwide. Recent studies have shown the role of dietary polyphenols in the prevention of obesity and obesity-related chronic diseases. Here, we evaluated the impact of commonly consumed polyphenols, including green tea catechins, especially epigallocatechin gallates, resveratrol and curcumin, on obesity and obesity-related inflammation. Cellular studies demonstrated that these dietary polyphenols reduce viability of adipocytes and proliferation of preadipocytes, suppress adipocyte differentiation and triglyceride accumulation, stimulate lipolysis and fatty acid β-oxidation, and reduce inflammation. Concomitantly, the polyphenols modulate signaling pathways including the adenosine-monophosphate-activated protein kinase, peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, peroxisome proliferator activator receptor gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor-κB that regulate adipogenesis, antioxidant and anti-inflammatory responses. Animal studies strongly suggest that commonly consumed polyphenols described in this review have a pronounced effect on obesity as shown by lower body weight, fat mass and triglycerides through enhancing energy expenditure and fat utilization, and modulating glucose hemostasis. Limited human studies have been conducted in this area and are inconsistent about the antiobesity impact of dietary polyphenols probably due to the various study designs and lengths, variation among subjects (age, gender, ethnicity), chemical forms of the dietary polyphenols used and confounding factors such as other weight-reducing agents. Future randomized controlled trials are warranted to reconcile the discrepancies between preclinical efficacies and inconclusive clinic outcomes of these polyphenols.
AB - The prevalence of obesity has steadily increased over the past three decades both in the United States and worldwide. Recent studies have shown the role of dietary polyphenols in the prevention of obesity and obesity-related chronic diseases. Here, we evaluated the impact of commonly consumed polyphenols, including green tea catechins, especially epigallocatechin gallates, resveratrol and curcumin, on obesity and obesity-related inflammation. Cellular studies demonstrated that these dietary polyphenols reduce viability of adipocytes and proliferation of preadipocytes, suppress adipocyte differentiation and triglyceride accumulation, stimulate lipolysis and fatty acid β-oxidation, and reduce inflammation. Concomitantly, the polyphenols modulate signaling pathways including the adenosine-monophosphate-activated protein kinase, peroxisome proliferator activated receptor γ, CCAAT/enhancer binding protein α, peroxisome proliferator activator receptor gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor-κB that regulate adipogenesis, antioxidant and anti-inflammatory responses. Animal studies strongly suggest that commonly consumed polyphenols described in this review have a pronounced effect on obesity as shown by lower body weight, fat mass and triglycerides through enhancing energy expenditure and fat utilization, and modulating glucose hemostasis. Limited human studies have been conducted in this area and are inconsistent about the antiobesity impact of dietary polyphenols probably due to the various study designs and lengths, variation among subjects (age, gender, ethnicity), chemical forms of the dietary polyphenols used and confounding factors such as other weight-reducing agents. Future randomized controlled trials are warranted to reconcile the discrepancies between preclinical efficacies and inconclusive clinic outcomes of these polyphenols.
KW - Animal
KW - Antioxidants
KW - Cell
KW - Dietary polyphenols
KW - Human
KW - Molecular mechanism
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84889564987&partnerID=8YFLogxK
U2 - 10.1016/j.jnutbio.2013.09.001
DO - 10.1016/j.jnutbio.2013.09.001
M3 - Article
C2 - 24314860
SN - 0955-2863
VL - 25
SP - 1
EP - 18
JO - The Journal of Nutritional Biochemistry
JF - The Journal of Nutritional Biochemistry
IS - 1
ER -