Novel approach to multifunctionalized homoallylic alcohols via regioselective ring opening of aryl oxiranes with 3-iodo allenoates

Adiseshu Kattuboina, Parminder Kaur, Cody Timmons, Guigen Li

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

3-Iodo allenoates were generated in situ and utilized, for the first time, in the ring opening of oxiranes in a regioselective fashion. This simple one-pot three-component reaction protocol provides easy access to highly functionalized homoallylic alcohols in good yields and moderate to very good (Z/E) selectivity. The two functional groups (ester and halogen) can be further subjected to many synthetic transformations.

Original languageEnglish
Pages (from-to)2771-2774
Number of pages4
JournalOrganic Letters
Volume8
Issue number13
DOIs
StatePublished - Jun 22 2006

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