Nickel-catalyzed decarboxylative acylation of heteroarenes by sp 2 C-H functionalization

Ke Yang, Cheng Zhang, Peng Wang, Yan Zhang, Haibo Ge

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Nickel-catalyzed ligand-free decarboxylative cross-coupling of azole derivatives with α-oxoglyoxylic acids has been developed. This work represents the first example of decarboxylative cross-coupling reactions, in a C-H bond functionalization manner, through nickel catalysis, and tolerates various functional groups. Additionally, this approach provides an efficient access to azole ketones, an important structural motif in many medicinal compounds with a broad range of biological activities.

Original languageEnglish
Pages (from-to)7241-7244
Number of pages4
JournalChemistry - A European Journal
Volume20
Issue number24
DOIs
StatePublished - Jun 10 2014

Keywords

  • acylation
  • decarboxylation
  • heteroarenes
  • nickel

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