Abstract
Nickel-catalyzed ligand-free decarboxylative cross-coupling of azole derivatives with α-oxoglyoxylic acids has been developed. This work represents the first example of decarboxylative cross-coupling reactions, in a C-H bond functionalization manner, through nickel catalysis, and tolerates various functional groups. Additionally, this approach provides an efficient access to azole ketones, an important structural motif in many medicinal compounds with a broad range of biological activities.
Original language | English |
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Pages (from-to) | 7241-7244 |
Number of pages | 4 |
Journal | Chemistry - A European Journal |
Volume | 20 |
Issue number | 24 |
DOIs | |
State | Published - Jun 10 2014 |
Keywords
- acylation
- decarboxylation
- heteroarenes
- nickel