New X-ray computed tomography system for laboratory mouse imaging

M. J. Paulus, H. Sari-Sarraf, S. S. Gleason, M. Bobrek, J. S. Hicks, D. K. Johnson, J. K. Behel, L. H. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Two versions of a new high-resolution x-ray computed tomography system are being developed to screen mutagenized mice in the Oak Ridge National Laboratory Mouse Genetics Research Facility. The first prototype employs a single pixel solid-state detector with a pinhole collimator operating in pulse counting mode. The second version employs a phosphor screen/CCD detector operating in current mode. The gantry consists of a low-energy x-ray tube, two linear translation stages and a rotational stage. For the single pixel detector image resolution is determined by the step size of the detector stage; preliminary images have been acquired at 100 μm and 250 μm resolutions. The resolution of the phosphor screen detector is determined by the modulation transfer function of the phosphor screen; images with resolutions approaching 50 μm have been acquired. The system performance with the two detectors is described and recent images are presented.

Original languageEnglish
Title of host publicationIEEE Nuclear Science Symposium and Medical Imaging Conference
PublisherIEEE
Pages1259-1263
Number of pages5
ISBN (Print)0780350227
StatePublished - Jan 1 1999
EventProceedings of the 1998 IEEE Nuclear Science Symposium Conference Record - Toronto, Que, Can
Duration: Nov 8 1998Nov 14 1998

Publication series

NameIEEE Nuclear Science Symposium and Medical Imaging Conference
Volume2

Conference

ConferenceProceedings of the 1998 IEEE Nuclear Science Symposium Conference Record
CityToronto, Que, Can
Period11/8/9811/14/98

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Paulus, M. J., Sari-Sarraf, H., Gleason, S. S., Bobrek, M., Hicks, J. S., Johnson, D. K., Behel, J. K., & Thompson, L. H. (1999). New X-ray computed tomography system for laboratory mouse imaging. In IEEE Nuclear Science Symposium and Medical Imaging Conference (pp. 1259-1263). (IEEE Nuclear Science Symposium and Medical Imaging Conference; Vol. 2). IEEE.