New synthesis of Evans chiral oxazolidinones by using Sharpless AA reaction

Guigen Li, Robert Lenington, Steven Willis, Sun Hee Kim

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Optically pure new Evans auxiliary analogs, (4R)- and (4S)-4-(2-naphthyl)oxazolidin-2-one, have been synthesized by using the Sharpless catalytic asymmetric aminohydroxylation reaction (Sharpless AA). The concise two-step synthesis involves a unique solution-to-solid Sharpless AA process and new neat cyclization conditions.

Original languageEnglish
Pages (from-to)1753-1754
Number of pages2
JournalJournal of the Chemical Society - Perkin Transactions 1
Issue number11
DOIs
StatePublished - Jun 7 1998

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