Optically pure new Evans auxiliary analogs, (4R)- and (4S)-4-(2-naphthyl)oxazolidin-2-one, have been synthesized by using the Sharpless catalytic asymmetric aminohydroxylation reaction (Sharpless AA). The concise two-step synthesis involves a unique solution-to-solid Sharpless AA process and new neat cyclization conditions.
|Number of pages||2|
|Journal||Journal of the Chemical Society - Perkin Transactions 1|
|State||Published - Jun 7 1998|