New multicomponent cyclization: Domino synthesis of pentasubstituted pyridines under solvent-free conditions

Bo Jiang, Xiang Wang, Feng Shi, Shu Jiang Tu, Guigen Li

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

An efficient methodology for the synthesis of highly functionalized pyridine derivatives starting from readily available common reactants has been developed under microwave irradiation and solvent-free conditions. The new domino reaction enables successful assembly of five new σ bonds including two C-N bonds in a one-pot operation. A new mechanism has been proposed, which involves a novel reaction and sequence consisting of deprotonation-imine formation-anionic carbonyl addition.

Original languageEnglish
Pages (from-to)4025-4028
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number11
DOIs
StatePublished - Jun 7 2011

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