New multicomponent cyclization: Domino synthesis of pentasubstituted pyridines under solvent-free conditions

Bo Jiang; Xiang Wang; Feng Shi; Shu Jiang Tu; Guigen Li

doi:10.1039/c0ob01258k

New multicomponent cyclization: Domino synthesis of pentasubstituted pyridines under solvent-free conditions

Bo Jiang, Xiang Wang, Feng Shi, Shu Jiang Tu, Guigen Li

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

An efficient methodology for the synthesis of highly functionalized pyridine derivatives starting from readily available common reactants has been developed under microwave irradiation and solvent-free conditions. The new domino reaction enables successful assembly of five new σ bonds including two C-N bonds in a one-pot operation. A new mechanism has been proposed, which involves a novel reaction and sequence consisting of deprotonation-imine formation-anionic carbonyl addition.

Original language	English
Pages (from-to)	4025-4028
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	11
DOIs	https://doi.org/10.1039/c0ob01258k
State	Published - Jun 7 2011

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title = "New multicomponent cyclization: Domino synthesis of pentasubstituted pyridines under solvent-free conditions",

abstract = "An efficient methodology for the synthesis of highly functionalized pyridine derivatives starting from readily available common reactants has been developed under microwave irradiation and solvent-free conditions. The new domino reaction enables successful assembly of five new σ bonds including two C-N bonds in a one-pot operation. A new mechanism has been proposed, which involves a novel reaction and sequence consisting of deprotonation-imine formation-anionic carbonyl addition.",

author = "Bo Jiang and Xiang Wang and Feng Shi and Tu, {Shu Jiang} and Guigen Li",

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T1 - New multicomponent cyclization

T2 - Domino synthesis of pentasubstituted pyridines under solvent-free conditions

AU - Jiang, Bo

AU - Wang, Xiang

AU - Shi, Feng

AU - Tu, Shu Jiang

AU - Li, Guigen

PY - 2011/6/7

Y1 - 2011/6/7

N2 - An efficient methodology for the synthesis of highly functionalized pyridine derivatives starting from readily available common reactants has been developed under microwave irradiation and solvent-free conditions. The new domino reaction enables successful assembly of five new σ bonds including two C-N bonds in a one-pot operation. A new mechanism has been proposed, which involves a novel reaction and sequence consisting of deprotonation-imine formation-anionic carbonyl addition.

AB - An efficient methodology for the synthesis of highly functionalized pyridine derivatives starting from readily available common reactants has been developed under microwave irradiation and solvent-free conditions. The new domino reaction enables successful assembly of five new σ bonds including two C-N bonds in a one-pot operation. A new mechanism has been proposed, which involves a novel reaction and sequence consisting of deprotonation-imine formation-anionic carbonyl addition.

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DO - 10.1039/c0ob01258k

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AN - SCOPUS:79956260862

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ER -

New multicomponent cyclization: Domino synthesis of pentasubstituted pyridines under solvent-free conditions

Abstract

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