New cytotoxic halogenated sesquiterpenes from the Egyptian sea hare, Aplysia oculifera

Mohamed Elamir F. Hegazy, Alaa Y. Moustfa, Abou El Hamd H. Mohamed, Montaser A. Alhammady, Serag Eldin I. Elbehairi, Shinji Ohta, Paul W. Paré

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Two new sesquiterpenes, oculiferane (1) and epi-obtusane (2) have been isolated and identified from an acetone extract of the digestive gland of the sea hare, Aplysia oculifera. The structures were elucidated by spectroscopic analysis including HREIMS, 1H, 13C, DEPT, 1H-1H COSY, HMQC, and HMBC NMR; the relative configuration was confirmed by X-ray analysis. Compounds 1 and 2 exhibited cytotoxic activity in vitro against several human cancer cell lines with IC50 values in the low μg/ml range.

Original languageEnglish
Pages (from-to)1711-1714
Number of pages4
JournalTetrahedron Letters
Volume55
Issue number10
DOIs
StatePublished - Mar 5 2014

Keywords

  • Aplysia oculifera
  • Cytotoxicity
  • Halogenated sesquiterpenes
  • Opisthobranch

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