New cytotoxic constituents from the Red Sea soft coral Nephthea sp

Mohamed Elamir F. Hegazy, Amira M. Gamal-Eldeen, Tarik A. Mohamed, Montaser A. Alhammady, Abuzeid A. Hassanien, Mohamed A. Shreadah, Ibrahim I. Abdelgawad, Eman M. Elkady, Paul W. Paré

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Nephthea are soft coral species rich in sesquiterpenoids and steroids. An organic extract of Nephthea sp. resulted in the isolation of a new steroid (1), as well as several previously reported metabolites (2-9). Structures were elucidated by employing NMR and HR-EI-MS analyses. The total extract, fractions and purified compounds exhibited differential cytotoxicity against the breast cancer MCF-7 cell line.

Original languageEnglish
Pages (from-to)1266-1272
Number of pages7
JournalNatural Product Research
Volume30
Issue number11
DOIs
StatePublished - 2016

Keywords

  • Breast cancer cell line MCF-7
  • Cytotoxicity
  • Nephthea sp
  • Terpenes

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