TY - JOUR
T1 - New cytotoxic constituents from the Red Sea soft coral Nephthea sp
AU - Hegazy, Mohamed Elamir F.
AU - Gamal-Eldeen, Amira M.
AU - Mohamed, Tarik A.
AU - Alhammady, Montaser A.
AU - Hassanien, Abuzeid A.
AU - Shreadah, Mohamed A.
AU - Abdelgawad, Ibrahim I.
AU - Elkady, Eman M.
AU - Paré, Paul W.
N1 - Publisher Copyright:
© 2015 Taylor & Francis.
PY - 2016
Y1 - 2016
N2 - Nephthea are soft coral species rich in sesquiterpenoids and steroids. An organic extract of Nephthea sp. resulted in the isolation of a new steroid (1), as well as several previously reported metabolites (2-9). Structures were elucidated by employing NMR and HR-EI-MS analyses. The total extract, fractions and purified compounds exhibited differential cytotoxicity against the breast cancer MCF-7 cell line.
AB - Nephthea are soft coral species rich in sesquiterpenoids and steroids. An organic extract of Nephthea sp. resulted in the isolation of a new steroid (1), as well as several previously reported metabolites (2-9). Structures were elucidated by employing NMR and HR-EI-MS analyses. The total extract, fractions and purified compounds exhibited differential cytotoxicity against the breast cancer MCF-7 cell line.
KW - Breast cancer cell line MCF-7
KW - Cytotoxicity
KW - Nephthea sp
KW - Terpenes
UR - http://www.scopus.com/inward/record.url?scp=84975883837&partnerID=8YFLogxK
U2 - 10.1080/14786419.2015.1055266
DO - 10.1080/14786419.2015.1055266
M3 - Article
C2 - 26165402
AN - SCOPUS:84975883837
SN - 1478-6419
VL - 30
SP - 1266
EP - 1272
JO - Natural Product Research
JF - Natural Product Research
IS - 11
ER -