Consistent with the ICIS conference theme "Gateway to the Future," this panel will debate the advantages of pursuing NeuroIS - an emerging area in the IS discipline that offers a new lens into IS phenomena by looking into the brain's functionality - relative to the challenges inherent in adopting a new set of neuroscience theories and tools. The panelists will debate whether the difficulties involved in conducting NeuroIS studies outweigh their benefits, and whether it is possible to overcome these challenges. Izak Benbasat will outline the process of conducting NeuroIS studies, including identifying interesting IS research problems, designing experiments, and presenting results. Kai Lim and Eric Walden will focus on the challenges of NeuroIS studies, while Angelika Dimoka will seek to counteract these challenges with a set of solutions. From an editor's perspective, Detmar Straub will discuss the challenges in editing and reviewing manuscripts that rely on novel (neuroscience) theories and (neurophysiological) tools, offering guidelines for authors for publishing in this new area. The panel seeks to have a broad appeal to IS researchers who may be interested in NeuroIS but may be impeded by its challenges. The panel's ultimate goal is to assess if these challenges could be overcome and give IS researchers a set of actionable solutions to conduct high-quality studies.