Neurodegenerative Implications of Neuronal Cytoplasmic Protein Dysfunction in Response to Environmental Contaminants

Research output: Contribution to journalReview articlepeer-review

Abstract

Neurodegenerative diseases account for a significant portion of public health concerns particularly in the aging population. The dysfunction of interfilament proteins has been identified as a key event in the initiation of neurodegeneration and subsequent progression to neurodegenerative diseases. In addition, several studies have found associations between the dysfunction of interfilament proteins and exposure to environmental contaminants. Therefore, in this review, the role of interfilament proteins in neuronal cells, their connection to neurotoxicity from environmental contaminants, and finally the resulting neurodegeneration are discussed.

Original languageEnglish
Pages (from-to)533-541
Number of pages9
JournalNeurotoxicity Research
Volume39
Issue number2
DOIs
StatePublished - Apr 2021

Keywords

  • Environmental contaminants
  • Neurodegeneration
  • Neurofilament proteins
  • Neurotoxicity

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