TY - JOUR
T1 - Neurodegenerative Implications of Neuronal Cytoplasmic Protein Dysfunction in Response to Environmental Contaminants
AU - Osemwegie, Odia
AU - Ramkumar, Seshadri
AU - Smith, Ernest E.
N1 - Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Neurodegenerative diseases account for a significant portion of public health concerns particularly in the aging population. The dysfunction of interfilament proteins has been identified as a key event in the initiation of neurodegeneration and subsequent progression to neurodegenerative diseases. In addition, several studies have found associations between the dysfunction of interfilament proteins and exposure to environmental contaminants. Therefore, in this review, the role of interfilament proteins in neuronal cells, their connection to neurotoxicity from environmental contaminants, and finally the resulting neurodegeneration are discussed.
AB - Neurodegenerative diseases account for a significant portion of public health concerns particularly in the aging population. The dysfunction of interfilament proteins has been identified as a key event in the initiation of neurodegeneration and subsequent progression to neurodegenerative diseases. In addition, several studies have found associations between the dysfunction of interfilament proteins and exposure to environmental contaminants. Therefore, in this review, the role of interfilament proteins in neuronal cells, their connection to neurotoxicity from environmental contaminants, and finally the resulting neurodegeneration are discussed.
KW - Environmental contaminants
KW - Neurodegeneration
KW - Neurofilament proteins
KW - Neurotoxicity
UR - http://www.scopus.com/inward/record.url?scp=85096025344&partnerID=8YFLogxK
U2 - 10.1007/s12640-020-00308-8
DO - 10.1007/s12640-020-00308-8
M3 - Review article
AN - SCOPUS:85096025344
JO - Neurotoxicity Research
JF - Neurotoxicity Research
SN - 1029-8428
ER -