Neurodegenerative Implications of Neuronal Cytoplasmic Protein Dysfunction in Response to Environmental Contaminants

Odia Osemwegie; Seshadri Ramkumar; Ernest E. Smith

doi:10.1007/s12640-020-00308-8

Neurodegenerative Implications of Neuronal Cytoplasmic Protein Dysfunction in Response to Environmental Contaminants

Odia Osemwegie, Seshadri Ramkumar, Ernest E. Smith

Environmental Toxicology

Research output: Contribution to journal › Review article › peer-review

Abstract

Neurodegenerative diseases account for a significant portion of public health concerns particularly in the aging population. The dysfunction of interfilament proteins has been identified as a key event in the initiation of neurodegeneration and subsequent progression to neurodegenerative diseases. In addition, several studies have found associations between the dysfunction of interfilament proteins and exposure to environmental contaminants. Therefore, in this review, the role of interfilament proteins in neuronal cells, their connection to neurotoxicity from environmental contaminants, and finally the resulting neurodegeneration are discussed.

Original language	English
Pages (from-to)	533-541
Number of pages	9
Journal	Neurotoxicity Research
Volume	39
Issue number	2
DOIs	https://doi.org/10.1007/s12640-020-00308-8
State	Published - Apr 2021

Keywords

Environmental contaminants
Neurodegeneration
Neurofilament proteins
Neurotoxicity

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10.1007/s12640-020-00308-8

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title = "Neurodegenerative Implications of Neuronal Cytoplasmic Protein Dysfunction in Response to Environmental Contaminants",

abstract = "Neurodegenerative diseases account for a significant portion of public health concerns particularly in the aging population. The dysfunction of interfilament proteins has been identified as a key event in the initiation of neurodegeneration and subsequent progression to neurodegenerative diseases. In addition, several studies have found associations between the dysfunction of interfilament proteins and exposure to environmental contaminants. Therefore, in this review, the role of interfilament proteins in neuronal cells, their connection to neurotoxicity from environmental contaminants, and finally the resulting neurodegeneration are discussed.",

keywords = "Environmental contaminants, Neurodegeneration, Neurofilament proteins, Neurotoxicity",

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AU - Ramkumar, Seshadri

AU - Smith, Ernest E.

PY - 2021/4

Y1 - 2021/4

N2 - Neurodegenerative diseases account for a significant portion of public health concerns particularly in the aging population. The dysfunction of interfilament proteins has been identified as a key event in the initiation of neurodegeneration and subsequent progression to neurodegenerative diseases. In addition, several studies have found associations between the dysfunction of interfilament proteins and exposure to environmental contaminants. Therefore, in this review, the role of interfilament proteins in neuronal cells, their connection to neurotoxicity from environmental contaminants, and finally the resulting neurodegeneration are discussed.

AB - Neurodegenerative diseases account for a significant portion of public health concerns particularly in the aging population. The dysfunction of interfilament proteins has been identified as a key event in the initiation of neurodegeneration and subsequent progression to neurodegenerative diseases. In addition, several studies have found associations between the dysfunction of interfilament proteins and exposure to environmental contaminants. Therefore, in this review, the role of interfilament proteins in neuronal cells, their connection to neurotoxicity from environmental contaminants, and finally the resulting neurodegeneration are discussed.

KW - Environmental contaminants

KW - Neurodegeneration

KW - Neurofilament proteins

KW - Neurotoxicity

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U2 - 10.1007/s12640-020-00308-8

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ER -

Neurodegenerative Implications of Neuronal Cytoplasmic Protein Dysfunction in Response to Environmental Contaminants

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Keywords

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