Neural correlates of state-based decision-making in younger and older adults

Darrell A. Worthy, Tyler Davis, Marissa A. Gorlick, Jessica A. Cooper, Akram Bakkour, Jeanette A. Mumford, Russell A. Poldrack, W. Todd Maddox

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Older and younger adults performed a state-based decision-making task while undergoing functional MRI (fMRI). We proposed that younger adults would be more prone to base their decisions on expected value comparisons, but that older adults would be more reactive decision-makers who would act in response to recent changes in rewards or states, rather than on a comparison of expected values. To test this we regressed BOLD activation on two measures from a sophisticated reinforcement learning (RL) model. A value-based regressor was computed by subtracting the immediate value of the selected alternative from its long-term value. The other regressor was a state-change uncertainty signal that served as a proxy for whether the participant's state improved or declined, relative to the previous trial. Younger adults' activation was modulated by the value-based regressor in ventral striatal and medial PFC regions implicated in reinforcement learning. Older adults' activation was modulated by state-change uncertainty signals in right dorsolateral PFC, and activation in this region was associated with improved performance in the task. This suggests that older adults may depart from standard expected-value based strategies and recruit lateral PFC regions to engage in reactive decision-making strategies.

Original languageEnglish
Pages (from-to)13-23
Number of pages11
JournalNeuroImage
Volume130
DOIs
StatePublished - Apr 15 2016

Keywords

  • Aging
  • Computational modeling
  • Decision-making
  • FMRI
  • Reinforcement learning

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    Worthy, D. A., Davis, T., Gorlick, M. A., Cooper, J. A., Bakkour, A., Mumford, J. A., Poldrack, R. A., & Todd Maddox, W. (2016). Neural correlates of state-based decision-making in younger and older adults. NeuroImage, 130, 13-23. https://doi.org/10.1016/j.neuroimage.2015.12.004