TY - GEN
T1 - Network motif-based identification of breast cancer susceptibility genes
AU - Zhang, Yuji
AU - Xuan, Jianhua
AU - De Los Reyes, Benilo G.
AU - Clarke, Robert
AU - Ressom, Habtom W.
PY - 2008
Y1 - 2008
N2 - Identifying breast cancer susceptibility genes is one of the key challenges in breast cancer research. Conventional gene-based approaches can identify patterns of gene activity that sub-classify tumors, by which genes with known breast cancer mutations are typically not detected. In this study, we present a novel network motif-based approach that integrates biological network topology and high-throughput gene expression data to identify markers not as individual genes but as network motifs. We observed that the network motifs are more reproducible than individual marker genes selected without biological network information, and that they achieve higher accuracy in the classification of metastatic versus non-metastatic tumors.
AB - Identifying breast cancer susceptibility genes is one of the key challenges in breast cancer research. Conventional gene-based approaches can identify patterns of gene activity that sub-classify tumors, by which genes with known breast cancer mutations are typically not detected. In this study, we present a novel network motif-based approach that integrates biological network topology and high-throughput gene expression data to identify markers not as individual genes but as network motifs. We observed that the network motifs are more reproducible than individual marker genes selected without biological network information, and that they achieve higher accuracy in the classification of metastatic versus non-metastatic tumors.
UR - http://www.scopus.com/inward/record.url?scp=61849132180&partnerID=8YFLogxK
U2 - 10.1109/iembs.2008.4650507
DO - 10.1109/iembs.2008.4650507
M3 - Conference contribution
C2 - 19164010
AN - SCOPUS:61849132180
SN - 9781424418152
T3 - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
SP - 5696
EP - 5699
BT - Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
PB - IEEE Computer Society
T2 - 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
Y2 - 20 August 2008 through 25 August 2008
ER -