Nanomedicine and nanoemulsion in increasing the availability of antibiotics

Xinli Liu, Wei Li

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

There is a pressing need for the discovery of new antimicrobials and novel, antimicrobial targeting strategies. Many antimicrobials in preclinical and clinical development have poor aqueous solubility, which limits their clinical development and usage due to the low bioavailability. Enhancement of bioavailability in antimicrobials is, therefore, of great importance for achieving therapeutically effective doses and desired concentrations of drugs for the treatment of infectious diseases. Nanomedicine has enormous potential for the prevention and treatment of infectious diseases. Nanoemulsion is one type of clinically useful formulation that can provide a substantial advantage over the conventional formulation of antibiotics since the antibacterial activity of antibiotics can be significantly enhanced by dispensing them in nanoparticulate dosage form. This sustained delivery system can help to deliver antibiotics with poor solubility and pharmaceutical properties, improve the systemic or local drug bioavailability and enhance the therapeutic efficacy.

Original languageEnglish
Title of host publicationAntibacterial Drug Discovery to Combat MDR
Subtitle of host publicationNatural Compounds, Nanotechnology and Novel Synthetic Sources
PublisherSpringer Singapore
Pages549-559
Number of pages11
ISBN (Electronic)9789811398711
ISBN (Print)9789811398704
DOIs
StatePublished - Jan 1 2019

Keywords

  • Antibiotics bioavailability
  • Antibiotics delivery
  • Emulsions
  • Nanoemulsions
  • Nanomedicine

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