Nanoconfinement Effects on the Glass Transition and Crystallization Behaviors of Nifedipine

Sixue Cheng, Gregory B. McKenna

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18 Scopus citations


The impact of nanoconfinement on the crystallization and glass transition behaviors of nifedipine (NIF) has been investigated using differential scanning calorimetry. Nanoconfinement was provided by imbibing the NIF into a porous medium (controlled pore glass, CPG), and results were compared with the unconfined bulk material. Consistent with previous results from the literature, both glass transition temperature T g and melting temperature T m decrease with decreasing pore size. The melting temperature was found to decrease with the reciprocal of pore diameter and could be analyzed with the Gibbs-Thomson equation. In addition, for confinement sizes of 7.5 and 12 nm, it was found that no cold-crystallization occurs upon heating from the glassy state to above the expected melting transition. Finally, at intermediate confinements we find evidence of a possible new, confinement-induced polymorph of NIF.

Original languageEnglish
Pages (from-to)856-866
Number of pages11
JournalMolecular Pharmaceutics
Issue number2
StatePublished - Feb 4 2019


  • amorphous pharmaceutical
  • cold-crystallization
  • glass transition
  • nifedipine
  • polymorphism


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