(n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: Mechanistic insights

Nishan S. Kalupahana, Kate J. Claycombe, Naima Moustaid-Moussa

Research output: Contribution to journalReview articlepeer-review

181 Scopus citations

Abstract

Obesity is associated with the metabolic syndrome, a significant risk factor for developing type 2 diabetes and cardiovascular diseases. Chronic low-grade inflammation occurring in the adipose tissue of obese individuals is causally linked to the pathogenesis of insulin resistance and the metabolic syndrome. Although the exact trigger of this inflammatory process is unknown, adipose tissue hypoxia, endoplasmic reticular stress, and saturated fatty acid-mediated activation of innate immune processes have been identified as important processes in these disorders. Furthermore, macrophages and T lymphocytes have important roles in orchestrating this immune process. Although energy restriction leading to weight loss is the primary dietary intervention to reverse these obesity-associated metabolic disorders, other interventions targeted at alleviating adipose tissue inflammation have not been explored in detail. In this regard, (n-3) PUFA of marine origin both prevent and reverse high-fat-diet-induced adipose tissue inflammation and insulin resistance in rodents. We provide an update on the pathogenesis of adipose tissue inflammation and insulin resistance in obesity and discuss potential mechanisms by which (n-3) PUFA prevent and reverse these changes and the implications in human health.

Original languageEnglish
Pages (from-to)304-316
Number of pages13
JournalAdvances in Nutrition
Volume2
Issue number4
DOIs
StatePublished - Jul 2011

Fingerprint Dive into the research topics of '(n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: Mechanistic insights'. Together they form a unique fingerprint.

Cite this