Multiple testing methodology

Alex Dmitrienko, Frank Bretz, Peter H. Westfall, James Troendle, Brian L. Wiens, Ajit C. Tamhane, Jason C. Hsu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

33 Scopus citations

Abstract

Multiplicity issues are encountered in a variety of pharmaceutical applications with multiple objectives. In a pre-clinical setting, the objectives can correspond to multiple genetic markers. In clinical applications, the objectives can be defined in terms of multiple dose levels, endpoints or subgroup analyses. Most common sources of multiplicity in clinical trials are listed below: Multiple dose-control comparisons are commonly included in dosefinding studies to evaluate efficacy and safety properties of a treatment compared to a control.

Original languageEnglish
Title of host publicationMultiple Testing Problems in Pharmaceutical Statistics
PublisherCRC Press
Pages35-98
Number of pages64
ISBN (Electronic)9781584889854
ISBN (Print)9781584889847
StatePublished - Jan 1 2009

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