@inbook{68e7048aafc54ed587f164e0357eacda,
title = "Multidrug Efflux Pumps in the Genus Erwinia: Physiology and Regulation of Efflux Pump Gene Expression",
abstract = "Plant pathogens belonging to the genus Erwinia cause diseases in several economically important plants. Plants respond to bacterial infection with a powerful chemical arsenal and signaling molecules to rid themselves of the microbes. Although our understanding of how Erwinia initiate infections in plants has become clear, a comprehensive understanding of how these bacteria rid themselves of noxious antimicrobial agents during the infection is important. Multidrug efflux pumps are key factors in bacterial resistance toward antibiotics by reducing the level of antimicrobial compounds in the bacterial cell. Erwinia induce the expression of efflux pump genes in response to plant-derived antimicrobials. The capability of Erwinia to co-opt plant defense signaling molecules such as salicylic acid to trigger multidrug efflux pumps might have developed to ensure bacterial survival in susceptible host plants. In this review, we discuss the developments in Erwinia efflux pumps, focusing in particular on efflux pump function and the regulation of efflux pump gene expression.",
keywords = "bacterial efflux, efflux pump, gene expression, plant–pathogen interaction",
author = "J. Thekkiniath and R. Ravirala and {San Francisco}, M.",
note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2016",
doi = "10.1016/bs.pmbts.2016.05.011",
language = "English",
isbn = "9780128093856",
series = "Progress in Molecular Biology and Translational Science",
publisher = "Elsevier B.V.",
pages = "131--149",
editor = "{San Francisco}, Brian and {San Francisco}, Michael",
booktitle = "Host-Microbe Interactions, 2016",
}