This study examined the relationship between multidimensional family functioning and personal growth initiative (PGI). Three higher order family-functioning clusters (i.e., Family Processes, Family Organization, and Personal Growth) were assessed as predictors of PGI. Participants were college students: 165 men and 171 women. In hierarchical regression for men, Family Processes and Family Organization accounted for significant unique portions of the variance in PGI. For women, Family Processes and Personal Growth accounted for significant unique portions of the variance in PGI. The family-functioning clusters accounted for 26% and 21% of the variance in PGI for men and women, respectively. Implications for research and practice are discussed.