TY - GEN
T1 - Multi-omic approaches for characterization of hepatocellular carcinoma
AU - Ressom, Habtom W.
AU - Di Poto, Cristina
AU - Ferrarini, Alessia
AU - Hu, Yunli
AU - Ranjbar, Mohammad R.Nezami
AU - Song, Ehwang
AU - Varghese, Rency S.
AU - Wang, Minkun
AU - Zhou, Shiyue
AU - Zhu, Rui
AU - Zuo, Yiming
AU - Tadesse, Mahlet G.
AU - Mechref, Yehia
N1 - Publisher Copyright:
© 2016 IEEE.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/10/13
Y1 - 2016/10/13
N2 - Multi-omic approaches offer the opportunity to characterize complex diseases such as cancer at various molecular levels. In this paper, we present transcriptomic, proteomic/glycoproteomic, glycomic, and metabolomic (TPGM) data we acquired by analysis of liver tissues from hepatocellular carcinoma (HCC) cases and patients with liver cirrhosis. We evaluated changes in the levels of transcripts, proteins, glycans, and metabolites between tumor and cirrhotic tissues by statistical methods. We demonstrated the potential of multi-omic approaches and network analysis to investigate the interactions among these biomolecules in the progression of liver cirrhosis to HCC. Also, we showed the significance of multi-omic approaches to identify pathways altered in HCC.
AB - Multi-omic approaches offer the opportunity to characterize complex diseases such as cancer at various molecular levels. In this paper, we present transcriptomic, proteomic/glycoproteomic, glycomic, and metabolomic (TPGM) data we acquired by analysis of liver tissues from hepatocellular carcinoma (HCC) cases and patients with liver cirrhosis. We evaluated changes in the levels of transcripts, proteins, glycans, and metabolites between tumor and cirrhotic tissues by statistical methods. We demonstrated the potential of multi-omic approaches and network analysis to investigate the interactions among these biomolecules in the progression of liver cirrhosis to HCC. Also, we showed the significance of multi-omic approaches to identify pathways altered in HCC.
UR - http://www.scopus.com/inward/record.url?scp=85009060577&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2016.7591467
DO - 10.1109/EMBC.2016.7591467
M3 - Conference contribution
C2 - 28269041
AN - SCOPUS:85009060577
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 3437
EP - 3440
BT - 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 16 August 2016 through 20 August 2016
ER -