Multi-channel chips to simulate pulmonary arterial hypertension (PAH) pathophysiology and screen anti-PAH drugs

Taslim A. Al-Hilal, Ali Keshavarz, Wei Li, Fakhrul Ahsan

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Pulmonary arterial hypertension (PAH) encompasses a group of disorders. Many facets concerning the development and progression of PAH remain unclear. PAH investigators use intact animal or cellular models that are not malleable enough to accommodate investigation of the overlapping cellular and molecular processes involved in the development of this disease. In this project, we developed a device, called PAH-on-a-chip, wherein we grew cells from arteries of PAH patients, the latter giving rise to various cellular phenomena resembling PAH pathophysiology. This miniaturized device will contribute enormously to our understanding of this under-investigated disorder and expediting drug development for PAH.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1068-1069
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: Oct 22 2017Oct 26 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Country/TerritoryUnited States
CitySavannah
Period10/22/1710/26/17

Keywords

  • Pathophysiology
  • Plexiform lesions
  • Pulmonary arterial hypertension

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