@inproceedings{6d5d4c7442644e2c82860e8876e40624,
title = "Multi-channel chips to simulate pulmonary arterial hypertension (PAH) pathophysiology and screen anti-PAH drugs",
abstract = "Pulmonary arterial hypertension (PAH) encompasses a group of disorders. Many facets concerning the development and progression of PAH remain unclear. PAH investigators use intact animal or cellular models that are not malleable enough to accommodate investigation of the overlapping cellular and molecular processes involved in the development of this disease. In this project, we developed a device, called PAH-on-a-chip, wherein we grew cells from arteries of PAH patients, the latter giving rise to various cellular phenomena resembling PAH pathophysiology. This miniaturized device will contribute enormously to our understanding of this under-investigated disorder and expediting drug development for PAH.",
keywords = "Pathophysiology, Plexiform lesions, Pulmonary arterial hypertension",
author = "Al-Hilal, {Taslim A.} and Ali Keshavarz and Wei Li and Fakhrul Ahsan",
note = "Funding Information: We are thankful to Dr. Roger Kamm for his support in the chip design and valuable insights into the results. We acknowledge Pulmonary Hypertension Breakthrough Initiatives (PHBI) specimen bank for providing the PAH-afflicted cells and Cardiovascular Medical Research and Education Fund (CMREF) for funding the owrk. Publisher Copyright: {\textcopyright} 17CBMS-0001.; null ; Conference date: 22-10-2017 Through 26-10-2017",
year = "2020",
language = "English",
series = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
publisher = "Chemical and Biological Microsystems Society",
pages = "1068--1069",
booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
}