Mouse model of Alzheimer's disease demonstrates differential effects of early disease pathology on various brain regions

Liting Deng; Vivek K. Gupta; Yunqi Wu; Kanishka Pushpitha; Nitin Chitranshi; Veer B. Gupta; Matthew J. Fitzhenry; Masoud Zabet Moghaddam; Tim Karl; Ghasem Hosseini Salekdeh; Stuart L. Graham; Paul A. Haynes; Mehdi Mirzaei

doi:10.1002/pmic.202000213

Mouse model of Alzheimer's disease demonstrates differential effects of early disease pathology on various brain regions

Liting Deng, Vivek K. Gupta, Yunqi Wu, Kanishka Pushpitha, Nitin Chitranshi, Veer B. Gupta, Matthew J. Fitzhenry, Masoud Zabet Moghaddam, Tim Karl, Ghasem Hosseini Salekdeh, Stuart L. Graham, Paul A. Haynes, Mehdi Mirzaei

Center for BioTechnology Genomics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Different parts of the brain are affected distinctively in various stages of the Alzheimer's disease (AD) pathogenesis. Identifying the biochemical changes in specific brain regions is key to comprehend the neuropathological mechanisms in early pre-symptomatic phases of AD. Quantitative proteomics profiling of four distinct areas of the brain of young APP/PS1 mouse model of AD was performed followed by biochemical pathway enrichment analysis. Findings revealed fundamental compositional and functional shifts even in the early stages of the disease. This novel study highlights unique proteome and biochemical pathway alterations in specific regions of the brain that underlie the early stages of AD pathology and will provide a framework for future longitudinal studies. The proteomics data were deposited into the ProteomeXchange Consortium via PRIDE with the identifier PXD019192.

Original language	English
Article number	2000213
Journal	Proteomics
Volume	21
Issue number	7-8
DOIs	https://doi.org/10.1002/pmic.202000213
State	Published - Apr 2021

Keywords

APP/PS1
Alzheimer's disease
amyloid beta
cerebellum
cortex
hippocampus
proteomics

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10.1002/pmic.202000213

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Deng, L., Gupta, V. K., Wu, Y., Pushpitha, K., Chitranshi, N., Gupta, V. B., Fitzhenry, M. J., Moghaddam, M. Z., Karl, T., Salekdeh, G. H., Graham, S. L., Haynes, P. A., & Mirzaei, M. (2021). Mouse model of Alzheimer's disease demonstrates differential effects of early disease pathology on various brain regions. Proteomics, 21(7-8), Article 2000213. https://doi.org/10.1002/pmic.202000213

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title = "Mouse model of Alzheimer's disease demonstrates differential effects of early disease pathology on various brain regions",

abstract = "Different parts of the brain are affected distinctively in various stages of the Alzheimer's disease (AD) pathogenesis. Identifying the biochemical changes in specific brain regions is key to comprehend the neuropathological mechanisms in early pre-symptomatic phases of AD. Quantitative proteomics profiling of four distinct areas of the brain of young APP/PS1 mouse model of AD was performed followed by biochemical pathway enrichment analysis. Findings revealed fundamental compositional and functional shifts even in the early stages of the disease. This novel study highlights unique proteome and biochemical pathway alterations in specific regions of the brain that underlie the early stages of AD pathology and will provide a framework for future longitudinal studies. The proteomics data were deposited into the ProteomeXchange Consortium via PRIDE with the identifier PXD019192.",

keywords = "APP/PS1, Alzheimer's disease, amyloid beta, cerebellum, cortex, hippocampus, proteomics",

author = "Liting Deng and Gupta, {Vivek K.} and Yunqi Wu and Kanishka Pushpitha and Nitin Chitranshi and Gupta, {Veer B.} and Fitzhenry, {Matthew J.} and Moghaddam, {Masoud Zabet} and Tim Karl and Salekdeh, {Ghasem Hosseini} and Graham, {Stuart L.} and Haynes, {Paul A.} and Mehdi Mirzaei",

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year = "2021",

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doi = "10.1002/pmic.202000213",

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AU - Deng, Liting

AU - Gupta, Vivek K.

AU - Wu, Yunqi

AU - Pushpitha, Kanishka

AU - Chitranshi, Nitin

AU - Gupta, Veer B.

AU - Fitzhenry, Matthew J.

AU - Moghaddam, Masoud Zabet

AU - Karl, Tim

AU - Salekdeh, Ghasem Hosseini

AU - Graham, Stuart L.

AU - Haynes, Paul A.

AU - Mirzaei, Mehdi

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AB - Different parts of the brain are affected distinctively in various stages of the Alzheimer's disease (AD) pathogenesis. Identifying the biochemical changes in specific brain regions is key to comprehend the neuropathological mechanisms in early pre-symptomatic phases of AD. Quantitative proteomics profiling of four distinct areas of the brain of young APP/PS1 mouse model of AD was performed followed by biochemical pathway enrichment analysis. Findings revealed fundamental compositional and functional shifts even in the early stages of the disease. This novel study highlights unique proteome and biochemical pathway alterations in specific regions of the brain that underlie the early stages of AD pathology and will provide a framework for future longitudinal studies. The proteomics data were deposited into the ProteomeXchange Consortium via PRIDE with the identifier PXD019192.

KW - APP/PS1

KW - Alzheimer's disease

KW - amyloid beta

KW - cerebellum

KW - cortex

KW - hippocampus

KW - proteomics

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DO - 10.1002/pmic.202000213

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VL - 21

JO - Proteomics

JF - Proteomics

IS - 7-8

M1 - 2000213

ER -

Mouse model of Alzheimer's disease demonstrates differential effects of early disease pathology on various brain regions

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Keywords

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