Molecular characterization of a putative sodium/iodide symporter in the South African clawed frog, Xenopus laevis

Deborah L. Carr, F. Laharrague, B. Kahn, T. A. Pressley, J. A. Carr

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We have identified a putative NIS that is expressed in the adult and developing X. laevis and is homologous to the mammalian NIS. The sequence is specifically expressed in stomach, kidney, ovaries, and fat bodies. We did not see expression in brain, heart, liver, small intestine, skeletal muscle, testes, or skin. Expression of the putative xNIS in the stomach is particularly interesting, given the fact that the stomach possessed the greatest radiolabeled iodide uptake of any nonthyroidal tissue examined. Furthermore, radiolabeled iodide uptake in the stomach was significantly blocked in frogs exposed for 2 weeks to AP. Further characterization of the xNIS will yield a promising tool for investigating iodide transport in amphibians, including how frogs sequester iodide from their environment and the mechanisms underlying perchlorate disruption of thyroid function and reproduction.

Original languageEnglish
Pages (from-to)711-712
Number of pages2
JournalAnnals of the New York Academy of Sciences
Volume986
DOIs
StatePublished - 2003

Keywords

  • Iodide
  • Sodium/iodide symporter (NIS)
  • Xenopus laevis

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