Molecular architecture and biomedical leads of terpenes from Red Sea marine invertebrates

Mohamed Elamir F. Hegazy, Tarik A. Mohamed, Montaser A. Alhammady, Alaa M. Shaheen, Eman H. Reda, Abdelsamed I. Elshamy, Mina Aziz, Paul W. Paré

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation. As a result, intense research activity has been devoted to characterizing invertebrate terpenes from both a chemical and biological standpoint. This review focuses on the chemistry and biology of terpene metabolites isolated from the Red Sea ecosystem, a unique marine biome with one of the highest levels of biodiversity and specifically rich in invertebrate species.

Original languageEnglish
Pages (from-to)3154-3181
Number of pages28
JournalMarine Drugs
Issue number5
StatePublished - May 1 2015


  • Biomedical leads
  • Marine ecosystem
  • Marine invertebrates
  • Red Sea
  • Terpenes


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