Molecular architecture and biomedical leads of terpenes from Red Sea marine invertebrates

Mohamed Elamir F. Hegazy; Tarik A. Mohamed; Montaser A. Alhammady; Alaa M. Shaheen; Eman H. Reda; Abdelsamed I. Elshamy; Mina Aziz; Paul W. Paré

doi:10.3390/md13053154

Molecular architecture and biomedical leads of terpenes from Red Sea marine invertebrates

Mohamed Elamir F. Hegazy, Tarik A. Mohamed, Montaser A. Alhammady, Alaa M. Shaheen, Eman H. Reda, Abdelsamed I. Elshamy, Mina Aziz, Paul W. Paré

Chemistry and Biochemistry

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation. As a result, intense research activity has been devoted to characterizing invertebrate terpenes from both a chemical and biological standpoint. This review focuses on the chemistry and biology of terpene metabolites isolated from the Red Sea ecosystem, a unique marine biome with one of the highest levels of biodiversity and specifically rich in invertebrate species.

Original language	English
Pages (from-to)	3154-3181
Number of pages	28
Journal	Marine Drugs
Volume	13
Issue number	5
DOIs	https://doi.org/10.3390/md13053154
State	Published - May 1 2015

Keywords

Biomedical leads
Marine ecosystem
Marine invertebrates
Red Sea
Terpenes

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10.3390/md13053154

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title = "Molecular architecture and biomedical leads of terpenes from Red Sea marine invertebrates",

abstract = "Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation. As a result, intense research activity has been devoted to characterizing invertebrate terpenes from both a chemical and biological standpoint. This review focuses on the chemistry and biology of terpene metabolites isolated from the Red Sea ecosystem, a unique marine biome with one of the highest levels of biodiversity and specifically rich in invertebrate species.",

keywords = "Biomedical leads, Marine ecosystem, Marine invertebrates, Red Sea, Terpenes",

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year = "2015",

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Molecular architecture and biomedical leads of terpenes from Red Sea marine invertebrates. / Hegazy, Mohamed Elamir F.; Mohamed, Tarik A.; Alhammady, Montaser A.; Shaheen, Alaa M.; Reda, Eman H.; Elshamy, Abdelsamed I.; Aziz, Mina; Paré, Paul W.

In: Marine Drugs, Vol. 13, No. 5, 01.05.2015, p. 3154-3181.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Molecular architecture and biomedical leads of terpenes from Red Sea marine invertebrates

AU - Hegazy, Mohamed Elamir F.

AU - Mohamed, Tarik A.

AU - Alhammady, Montaser A.

AU - Shaheen, Alaa M.

AU - Reda, Eman H.

AU - Elshamy, Abdelsamed I.

AU - Aziz, Mina

AU - Paré, Paul W.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation. As a result, intense research activity has been devoted to characterizing invertebrate terpenes from both a chemical and biological standpoint. This review focuses on the chemistry and biology of terpene metabolites isolated from the Red Sea ecosystem, a unique marine biome with one of the highest levels of biodiversity and specifically rich in invertebrate species.

AB - Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation. As a result, intense research activity has been devoted to characterizing invertebrate terpenes from both a chemical and biological standpoint. This review focuses on the chemistry and biology of terpene metabolites isolated from the Red Sea ecosystem, a unique marine biome with one of the highest levels of biodiversity and specifically rich in invertebrate species.

KW - Biomedical leads

KW - Marine ecosystem

KW - Marine invertebrates

KW - Red Sea

KW - Terpenes

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