Modulation of EEG spectral edge frequency during patterned pneumatic oral stimulation in preterm infants

D Song, P Jegatheesan, S Weiss, B Govindaswami, J Wang, Jae Hoon Lee, A Oder, S M Barlow

Research output: Contribution to journalArticlepeer-review

Abstract

Stimulation of the nervous system plays a central role in brain development and neurodevelopmental outcomes. Thalamocortical and corticocortical development is diminished in premature infants and correlated to electroencephalography (EEG) progression. The purpose of this study was to determine the effects of orocutaneous stimulation on the modulation of spectral edge frequency fc = 90% (SEF-90), which is derived from EEG recordings in preterm infants. METHODS: A total of 22 preterm infants were randomized to experimental and control conditions. Pulsed orocutaneous stimulation was presented during gavage feedings begun at ~32 wk postmenstrual age. The SEF-90 was derived from two-channel EEG recordings. RESULTS: Compared with the control condition, the pulsed orocutaneous stimulation produced a significant reorganization of SEF-90 in the left (P = 0.005) and right (P < 0.0001) hemispheres. Notably, the left and right hemispheres showed a reversal in the polarity of frequency shift, demo
Original languageEnglish
Pages (from-to)85–92
JournalPediatric Research
StatePublished - 2014

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