TY - JOUR
T1 - Modulation of adipose tissue inflammation by bioactive food compounds
AU - Siriwardhana, Nalin
AU - Kalupahana, Nishan S.
AU - Cekanova, Maria
AU - LeMieux, Monique
AU - Greer, Betty
AU - Moustaid-Moussa, Naima
N1 - Funding Information:
This work was supported by a University of Tennessee AgResearch and Extension Innovation grant and Texas Tech University/College of Human Sciences .
PY - 2013/4
Y1 - 2013/4
N2 - Adipose tissue has an important endocrine function in the regulation of whole-body metabolism. Obesity leads to a chronic low-grade inflammation of the adipose tissue, which disrupts this endocrine function and results in metabolic derangements, such as type-2 diabetes. Dietary bioactive compounds, such as polyphenols and certain fatty acids, are known to suppress both systemic and adipose tissue inflammation and have the potential to improve these obesity-associated metabolic disorders. Mechanistically, polyphenolic compounds including non-flavonoids, such as curcumin and resveratrol, and flavonoids, such as catechins (tea-polyphenols), quercetin and isoflavones, suppress nuclear factor-κB (NF-κB) and mitogen-activated protein (MAP) kinases (MAPK) pathways while activating the 5' adenosine monophosphate-activated protein kinase (AMPK) pathway in adipose tissue. Dietary polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), conjugated linoleic acid (CLA) and monounsaturated fatty acids (MUFA), such as oleic acid, also impart anti-inflammatory effects through several mechanisms. These include activation of AMPK and peroxisome proliferator-activated receptor gamma (PPAR-γ), as well as suppression of toll-like receptors (TLRs) and NF-κB pathway. This review discusses the major molecular mechanisms of dietary polyphenols and fatty acids, alone or in combination, which are responsible for adipose tissue-associated anti-inflammatory effects.
AB - Adipose tissue has an important endocrine function in the regulation of whole-body metabolism. Obesity leads to a chronic low-grade inflammation of the adipose tissue, which disrupts this endocrine function and results in metabolic derangements, such as type-2 diabetes. Dietary bioactive compounds, such as polyphenols and certain fatty acids, are known to suppress both systemic and adipose tissue inflammation and have the potential to improve these obesity-associated metabolic disorders. Mechanistically, polyphenolic compounds including non-flavonoids, such as curcumin and resveratrol, and flavonoids, such as catechins (tea-polyphenols), quercetin and isoflavones, suppress nuclear factor-κB (NF-κB) and mitogen-activated protein (MAP) kinases (MAPK) pathways while activating the 5' adenosine monophosphate-activated protein kinase (AMPK) pathway in adipose tissue. Dietary polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), conjugated linoleic acid (CLA) and monounsaturated fatty acids (MUFA), such as oleic acid, also impart anti-inflammatory effects through several mechanisms. These include activation of AMPK and peroxisome proliferator-activated receptor gamma (PPAR-γ), as well as suppression of toll-like receptors (TLRs) and NF-κB pathway. This review discusses the major molecular mechanisms of dietary polyphenols and fatty acids, alone or in combination, which are responsible for adipose tissue-associated anti-inflammatory effects.
KW - Adipose tissue
KW - Curcumin
KW - Inflammation
KW - Monounsaturated fatty acids
KW - Obesity
KW - Phytochemicals
KW - Polyunsaturated fatty acids
KW - Quercetin
KW - Resveratrol
KW - Tea polyphenols
UR - http://www.scopus.com/inward/record.url?scp=84875078504&partnerID=8YFLogxK
U2 - 10.1016/j.jnutbio.2012.12.013
DO - 10.1016/j.jnutbio.2012.12.013
M3 - Review article
C2 - 23498665
AN - SCOPUS:84875078504
SN - 0955-2863
VL - 24
SP - 613
EP - 623
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
IS - 4
ER -