Modeling the dynamical response of biological cells

R. P. Joshi; Q. Hu; K. H. Schoenbach; V. K. Lakdawala

Modeling the dynamical response of biological cells

R. P. Joshi, Q. Hu, K. H. Schoenbach, V. K. Lakdawala

Electrical and Computer Engineering

Research output: Contribution to journal › Conference article › peer-review

Abstract

The dynamics of cell membrane response to nanosecond, high intensity pulses are studied based on a molecular dynamics (MD) approach. We focus on the cell membrane since the higehest electric fields in any biological system will develop across such insulating sheaths. Our simulations focus on membrane rupture and pore formation. In a sense, these phenomena correspond to an internal structural breakdown. It is shown that field-induced changes in membrane permeabilization is due to microscopic deformations at the molecular level. For simplicity course-grained representations are used instead of a full atomistic scheme, and our results agree with available reports.

Original language	English
Pages (from-to)	344-347
Number of pages	4
Journal	Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP
State	Published - 2004
Event	2004 Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP - Boulder, CO, United States Duration: Oct 17 2004 → Oct 20 2004

Cite this

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title = "Modeling the dynamical response of biological cells",

abstract = "The dynamics of cell membrane response to nanosecond, high intensity pulses are studied based on a molecular dynamics (MD) approach. We focus on the cell membrane since the higehest electric fields in any biological system will develop across such insulating sheaths. Our simulations focus on membrane rupture and pore formation. In a sense, these phenomena correspond to an internal structural breakdown. It is shown that field-induced changes in membrane permeabilization is due to microscopic deformations at the molecular level. For simplicity course-grained representations are used instead of a full atomistic scheme, and our results agree with available reports.",

author = "Joshi, {R. P.} and Q. Hu and Schoenbach, {K. H.} and Lakdawala, {V. K.}",

year = "2004",

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journal = "Conference on Electrical Insulation and Dielectric Phenomena (CEIDP), Annual Report",

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note = "2004 Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP ; Conference date: 17-10-2004 Through 20-10-2004",

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TY - JOUR

T1 - Modeling the dynamical response of biological cells

AU - Joshi, R. P.

AU - Hu, Q.

AU - Schoenbach, K. H.

AU - Lakdawala, V. K.

PY - 2004

Y1 - 2004

N2 - The dynamics of cell membrane response to nanosecond, high intensity pulses are studied based on a molecular dynamics (MD) approach. We focus on the cell membrane since the higehest electric fields in any biological system will develop across such insulating sheaths. Our simulations focus on membrane rupture and pore formation. In a sense, these phenomena correspond to an internal structural breakdown. It is shown that field-induced changes in membrane permeabilization is due to microscopic deformations at the molecular level. For simplicity course-grained representations are used instead of a full atomistic scheme, and our results agree with available reports.

AB - The dynamics of cell membrane response to nanosecond, high intensity pulses are studied based on a molecular dynamics (MD) approach. We focus on the cell membrane since the higehest electric fields in any biological system will develop across such insulating sheaths. Our simulations focus on membrane rupture and pore formation. In a sense, these phenomena correspond to an internal structural breakdown. It is shown that field-induced changes in membrane permeabilization is due to microscopic deformations at the molecular level. For simplicity course-grained representations are used instead of a full atomistic scheme, and our results agree with available reports.

UR - http://www.scopus.com/inward/record.url?scp=17744362661&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:17744362661

SN - 0084-9162

SP - 344

EP - 347

JO - Conference on Electrical Insulation and Dielectric Phenomena (CEIDP), Annual Report

JF - Conference on Electrical Insulation and Dielectric Phenomena (CEIDP), Annual Report

T2 - 2004 Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP

Y2 - 17 October 2004 through 20 October 2004

ER -

Modeling the dynamical response of biological cells

Abstract

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