Modeling the dynamical response of biological cells

R. P. Joshi, Q. Hu, K. H. Schoenbach, V. K. Lakdawala

Research output: Contribution to journalConference article

Abstract

The dynamics of cell membrane response to nanosecond, high intensity pulses are studied based on a molecular dynamics (MD) approach. We focus on the cell membrane since the higehest electric fields in any biological system will develop across such insulating sheaths. Our simulations focus on membrane rupture and pore formation. In a sense, these phenomena correspond to an internal structural breakdown. It is shown that field-induced changes in membrane permeabilization is due to microscopic deformations at the molecular level. For simplicity course-grained representations are used instead of a full atomistic scheme, and our results agree with available reports.

Original languageEnglish
Pages (from-to)344-347
Number of pages4
JournalAnnual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP
StatePublished - 2004
Event2004 Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP - Boulder, CO, United States
Duration: Oct 17 2004Oct 20 2004

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