Modeling studies of cellular response to ultrashort, high-intensity electric fields

R. P. Joshi, Q. Hu, K. H. Schoenbach, V. K. Lakdawala

Research output: Contribution to journalConference article

1 Scopus citations

Abstract

The dynamics of electroporation in biological cells subjected to nanosecond, high intensity pulses are studied based on a coupled scheme involving current continuity and Smoluchowski equations. A new distributed current model is presented for potential distribution to includes dynamic conductivities of cell membranes and substructures caused by pore formation. Different cell responses of normal and malignant (Farage) tonsillar B-cells are compared and discussed. It is shown that ultrashort, high-intensity electric pulses could selectively damage cancer cells.

Original languageEnglish
Pages (from-to)357-360
Number of pages4
JournalConference on Electrical Insulation and Dielectric Phenomena (CEIDP), Annual Report
StatePublished - 2003
Event2003 Annual Report: Conference on Electrical Insulation and Dieletric Phenomena - Albuquerque, NM, United States
Duration: Oct 19 2003Oct 22 2003

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