Modeling studies of cell response to ultrashort, high-intensity electric fields - Implications for intracellular manipulation

Ravindra P. Joshi, Qin Hu, Karl H. Schoenbach

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

The dynamics of electroporation in biological cells subjected to nanosecond, high-intensity pulses are studied based on a coupled scheme involving both the current continuity and Smoluchowski equations. A new distributed network model, that includes dynamic conductivities of cell membranes and substructures, is introduced for evaluations of transmembrane potential. It is shown that subcellular structures could be affected through nanosecond pulses, and that, despite the high field intensity, the processes remain nonthermal. As an example of selectivity, differences in cell responses between normal and malignant (Farage) tonsillar B-cells are compared and discussed. It is shown that ultrashort, high-intensity electric pulses could damage cancer cells. Finally, the model predicts that it is possible to target the inner mitochondrial membrane (i.e., selectivity at the organelle level), in keeping with recent experimental observations.

Original languageEnglish
Pages (from-to)1677-1686
Number of pages10
JournalIEEE Transactions on Plasma Science
Volume32
Issue number4 II
DOIs
StatePublished - Aug 2004

Fingerprint Dive into the research topics of 'Modeling studies of cell response to ultrashort, high-intensity electric fields - Implications for intracellular manipulation'. Together they form a unique fingerprint.

  • Cite this