Model study of time-dependent muscle response to pulsed electrical stimulation

Ravindra P. Joshi; Ashutosh Mishra; Shu Xiao; Anderi Pakhomov

doi:10.1002/bem.20566

Model study of time-dependent muscle response to pulsed electrical stimulation

Ravindra P. Joshi, Ashutosh Mishra, Shu Xiao, Anderi Pakhomov

Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A systems-level model analysis of neuromuscular response to external electrical stimulation is presented. Action potential (AP) generation, dynamics of voltage-based calcium release at the motor endplates controlled by the arrival of APs, and muscle force production are all comprehensively included. Numerical predictions exhibit trends that are qualitatively similar to measurements of muscle response in rats from a burst of cortical stimulation and a nanosecond impulse. Modulation of neural membrane conductances (including possible electroporation) that alters the neural impulse generation frequency is hypothesized as a possible mechanism leading to observed changes in muscle force production. Other possibilities such as calcium release at nerve end endings also exist. It is also proposed that multipulsing strategies and changing the electric field direction by using multielectrode systems would be useful. 2010.

Original language	English
Pages (from-to)	361-370
Number of pages	10
Journal	Bioelectromagnetics
Volume	31
Issue number	5
DOIs	https://doi.org/10.1002/bem.20566
State	Published - Jul 2010

Keywords

Calcium dynamics
Electroporation
High-voltage pulsing
Modeling
Muscle force

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AB - A systems-level model analysis of neuromuscular response to external electrical stimulation is presented. Action potential (AP) generation, dynamics of voltage-based calcium release at the motor endplates controlled by the arrival of APs, and muscle force production are all comprehensively included. Numerical predictions exhibit trends that are qualitatively similar to measurements of muscle response in rats from a burst of cortical stimulation and a nanosecond impulse. Modulation of neural membrane conductances (including possible electroporation) that alters the neural impulse generation frequency is hypothesized as a possible mechanism leading to observed changes in muscle force production. Other possibilities such as calcium release at nerve end endings also exist. It is also proposed that multipulsing strategies and changing the electric field direction by using multielectrode systems would be useful. 2010.

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Model study of time-dependent muscle response to pulsed electrical stimulation

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