TY - JOUR
T1 - Model evaluation of changes in electrorotation spectra of biological cells after nsPEF electroporation
AU - Hu, Q.
AU - Joshi, R. P.
N1 - Funding Information:
The authors thank Prof. K. H. Schoenbach (Old Dominion University) and Prof. D. Miklavcic (Univ. Ljubljana) for useful discussions. The support from the Office of Research and Sponsored Programs (ORSP) of Central Michigan University is also gratefully acknowledged.
PY - 2010/12
Y1 - 2010/12
N2 - Cellular electroporation involves electrically driven dielectric membrane breakdown, and has several bio-medical applications. Electrorotation and changes in its characteristic spectra could be a useful method for monitoring electroporation. Towards this goal, a simulation analyses is presented to probe electrorotation features arising from poration. Breakdown of both outer plasma membrane and inner organelle membranes are included based on a double-shell dielectric model. Our results demonstrate the feasibility of such monitoring, and show that anti-field rotation would be a good indicator of outer plasma membrane rupture, and the degree of poration.
AB - Cellular electroporation involves electrically driven dielectric membrane breakdown, and has several bio-medical applications. Electrorotation and changes in its characteristic spectra could be a useful method for monitoring electroporation. Towards this goal, a simulation analyses is presented to probe electrorotation features arising from poration. Breakdown of both outer plasma membrane and inner organelle membranes are included based on a double-shell dielectric model. Our results demonstrate the feasibility of such monitoring, and show that anti-field rotation would be a good indicator of outer plasma membrane rupture, and the degree of poration.
KW - Electrorotation
KW - bio-electric simulation
KW - cellular electroporation
KW - transmembrane voltage
KW - ultrashort pulse
UR - http://www.scopus.com/inward/record.url?scp=78649993682&partnerID=8YFLogxK
U2 - 10.1109/TDEI.2010.5658243
DO - 10.1109/TDEI.2010.5658243
M3 - Article
AN - SCOPUS:78649993682
SN - 1070-9878
VL - 17
SP - 1888
EP - 1894
JO - IEEE Transactions on Dielectrics and Electrical Insulation
JF - IEEE Transactions on Dielectrics and Electrical Insulation
IS - 6
M1 - 5658243
ER -