Model evaluation of changes in electrorotation spectra of biological cells after nsPEF electroporation

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Abstract

Cellular electroporation involves electrically driven dielectric membrane breakdown, and has several bio-medical applications. Electrorotation and changes in its characteristic spectra could be a useful method for monitoring electroporation. Towards this goal, a simulation analyses is presented to probe electrorotation features arising from poration. Breakdown of both outer plasma membrane and inner organelle membranes are included based on a double-shell dielectric model. Our results demonstrate the feasibility of such monitoring, and show that anti-field rotation would be a good indicator of outer plasma membrane rupture, and the degree of poration.

Original languageEnglish
Article number5658243
Pages (from-to)1888-1894
Number of pages7
JournalIEEE Transactions on Dielectrics and Electrical Insulation
Volume17
Issue number6
DOIs
StatePublished - Dec 2010

Keywords

  • Electrorotation
  • bio-electric simulation
  • cellular electroporation
  • transmembrane voltage
  • ultrashort pulse

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