TY - JOUR
T1 - Model analysis of electric fields induced by high-voltage pulsing in cylindrical nerves
AU - Joshi, Ravindra P.
AU - Song, Jiahui
N1 - Funding Information:
Manuscript received April 27, 2010; revised June 15, 2010; accepted July 22, 2010. Date of publication August 19, 2010; date of current version October 8, 2010. This work was supported in part by the Office of Naval Research, Arlington, VA.
PY - 2010/10
Y1 - 2010/10
N2 - A cylindrical dielectric model is used to compute transmembrane potential changes and evaluate the axial electric field magnitudes produced within a nerve by a high-intensity relatively short electrical pulse. For concreteness, the pulse was taken to have a duration of about 700 ns and large current magnitudes in keeping with ongoing experimental studies within our group. Interest in this quantitative analysis arises from probing the possibility of triggering bioeffects at intracellular organelles in tissues (or even whole animals) through such electric stimulation. Almost all other studies have focused on simple spherical cells. This paper provides a theoretical framework for computing electric fields (especially the axial components) within such cylindrical geometries (e.g., nerve cells). It is shown that fields can become sufficiently high within microseconds and initiate electroporation, modulate electrochemical processes (e.g., calcium release), or trigger secondary biochemical effects depending on the electrical pulsing parameters.
AB - A cylindrical dielectric model is used to compute transmembrane potential changes and evaluate the axial electric field magnitudes produced within a nerve by a high-intensity relatively short electrical pulse. For concreteness, the pulse was taken to have a duration of about 700 ns and large current magnitudes in keeping with ongoing experimental studies within our group. Interest in this quantitative analysis arises from probing the possibility of triggering bioeffects at intracellular organelles in tissues (or even whole animals) through such electric stimulation. Almost all other studies have focused on simple spherical cells. This paper provides a theoretical framework for computing electric fields (especially the axial components) within such cylindrical geometries (e.g., nerve cells). It is shown that fields can become sufficiently high within microseconds and initiate electroporation, modulate electrochemical processes (e.g., calcium release), or trigger secondary biochemical effects depending on the electrical pulsing parameters.
KW - High-voltage pulsing
KW - induced axial fields
KW - nerve modeling
KW - neuromuscular junction effects
UR - http://www.scopus.com/inward/record.url?scp=77957894562&partnerID=8YFLogxK
U2 - 10.1109/TPS.2010.2063717
DO - 10.1109/TPS.2010.2063717
M3 - Article
AN - SCOPUS:77957894562
SN - 0093-3813
VL - 38
SP - 2894
EP - 2900
JO - IEEE Transactions on Plasma Science
JF - IEEE Transactions on Plasma Science
IS - 10 PART 2
M1 - 5551223
ER -