TY - JOUR
T1 - Mobile element-based forensic genomics
AU - Ray, David A.
AU - Walker, Jerilyn A.
AU - Batzer, Mark A.
N1 - Funding Information:
This research was supported by the Louisiana Board of Regents Governor's Biotechnology Initiative GBI (2002-005) (MAB), National Science Foundation EPS-0346411 (M.A.B.) and the State of Louisiana Board of Regents Support Fund (MAB).
PY - 2007/3/1
Y1 - 2007/3/1
N2 - Mobile elements are commonly referred to as selfish repetitive DNA sequences. However, mobile elements represent a unique and underutilized group of molecular markers. Several of their characteristics make them ideally suited for use as tools in forensic genomic applications. These include their nature as essentially homoplasy-free characters, they are identical by descent, the ancestral state of any insertion is known to be the absence of the element, and many mobile element insertions are lineage specific. In this review, we provide an overview of mobile element biology and describe the application of certain mobile elements, especially the SINEs and other retrotransposons, to forensic genomics. These tools include quantitative species-specific DNA detection, analysis of complex biomaterials, and the inference of geographic origin of human DNA samples.
AB - Mobile elements are commonly referred to as selfish repetitive DNA sequences. However, mobile elements represent a unique and underutilized group of molecular markers. Several of their characteristics make them ideally suited for use as tools in forensic genomic applications. These include their nature as essentially homoplasy-free characters, they are identical by descent, the ancestral state of any insertion is known to be the absence of the element, and many mobile element insertions are lineage specific. In this review, we provide an overview of mobile element biology and describe the application of certain mobile elements, especially the SINEs and other retrotransposons, to forensic genomics. These tools include quantitative species-specific DNA detection, analysis of complex biomaterials, and the inference of geographic origin of human DNA samples.
KW - Forensic genomics
KW - Mobile element
KW - SINEs
UR - http://www.scopus.com/inward/record.url?scp=33846704655&partnerID=8YFLogxK
U2 - 10.1016/j.mrfmmm.2006.11.019
DO - 10.1016/j.mrfmmm.2006.11.019
M3 - Article
C2 - 17161440
AN - SCOPUS:33846704655
SN - 0027-5107
VL - 616
SP - 24
EP - 33
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 1-2
ER -