Microwave enabled umpulong mechanism based rapid and efficient four- and six-component domino formations of 2-(2′-azaaryl)imidazoles and anti-1,2-diarylethylbenzamides

Bo Jiang, Xiang Wang, Feng Shi, Shu Jiang Tu, Teng Ai, Austin Ballew, Guigen Li

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

(Chemical Equation Presented) Concise and efficient six-component and four-component domino approaches to anti-1,2-diarylethylbenzamides and highly substituted 2-(2′-azaaryl)imidazoles have been developed under solvent-free and microwave-irradiation conditions. The reactions showed a broad scope of substrates in which a wide range of common commercial aromatic aldehydes and heteroaryl nitriles can be used. The syntheses were finished within short periods (15-34 min) with good to excellent chemical yields and stereoselectivity that avoided tedious workup isolations. New mechanisms involving an umpolung have been proposed for these two reaction processes.

Original languageEnglish
Pages (from-to)9486-9489
Number of pages4
JournalJournal of Organic Chemistry
Volume74
Issue number24
DOIs
StatePublished - Dec 18 2009

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