Microwave-Assisted multicomponent reaction in water: Highly stereoselective synthesis of pyrimidinespiroisoxazolo[5,4-b]pyridine derivatives

Bo Jiang, Ning Ma, Xing Han Wang, Shu Jiang Tu, Guigen Li

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A multicomponent reaction has been established for the synthesis of pyrimidinespiroisoxazolo[5,4-b]pyridines that can serve as versatile building blocks for both organic and medicinal research. The reasonable reaction mechanism has proposed to explain the resulting stereochemistry of products. The present green synthesis shows several advantages including operational simplicity and fast reaction rate, which makes it a useful and attractive process for library generation for drug discovery.

Original languageEnglish
Pages (from-to)765-774
Number of pages10
JournalHeterocycles
Volume84
Issue number2
DOIs
StatePublished - 2012

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