Microwave-assisted multi-component reaction in water leading to highly regioselective formation of benzo[f]azulen-1-ones

Shu Liang Wang, Chuang Cheng, Fei Yue Wu, Bo Jiang, Feng Shi, Shu Jiang Tu, Trideep Rajale, Guigen Li

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Microwave-assisted three-component reaction has been established for the regioselective synthesis of benzo[f]azulen-1-ones. The reaction was performed in aqueous media under microwave irradiation by using readily available and inexpensive starting materials. A total of 38 examples were examined to show a broad substrate scope and good overall yields (70-89%). The present new synthesis shows attractive green chemistry characteristics, such as the use of water as reaction media, concise one-pot conditions, short reaction periods (7-24 min), easy work-up/purification, and reduced waste production without the use of any strong acids or metal promoters.

Original languageEnglish
Pages (from-to)4485-4493
Number of pages9
JournalTetrahedron
Volume67
Issue number25
DOIs
StatePublished - Jun 24 2011

Keywords

  • Aqueous media
  • Benzo[f]azulen-1-ones
  • Green synthesis
  • Microwave-assisted multi-component reaction
  • Tetronic acid

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