Microwave-assisted combinatorial synthesis of polysubstituent imidazo[1,2-a]quinoline, pyrimido[1,2-a]quinoline and quinolino[1,2-a] quinazoline derivatives

Shujiang Tu, Chunmei Li, Guigen Li, Longji Cao, Qingqing Shao, Dianxiang Zhou, Bo Jiang, Jianfeng Zhou, Min Xia

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82 Scopus citations

Abstract

A series of unusual fused heterocyclic compound derivatives, consisting of a pyridine and a imidazole or pyrimidine core, with a bridgehead nitrogen, were successfully synthesized by a microwave-assisted, three-component domino reaction of aldehydes, enaminones, and malononnitrile. In this one-pot reaction, up to five new bonds were formed accompanied by generating the lactam group. This method has the advantages of short synthetic route, operational simplicity, increased safety for small-scale high-speed synthesis, and minimal environment impact.

Original languageEnglish
Pages (from-to)1144-1148
Number of pages5
JournalJournal of Combinatorial Chemistry
Volume9
Issue number6
DOIs
StatePublished - Nov 2007

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