MicroRNAs, Aging, Cellular Senescence, and Alzheimer's Disease

P. H. Reddy, J. Williams, F. Smith, J. S. Bhatti, S. Kumar, M. Vijayan, R. Kandimalla, C. S. Kuruva, R. Wang, M. Manczak, X. Yin, A. P. Reddy

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Scopus citations

Abstract

Aging is a normal process of living being. It has been reported that multiple cellular changes, including oxidative damage/mitochondrial dysfunction, telomere shortening, inflammation, may accelerate the aging process, leading to cellular senescence. These cellular changes induce age-related human diseases, including Alzheimer's, Parkinson's, multiple sclerosis, amyotrophic lateral sclerosis, cardiovascular, cancer, and skin diseases. Changes in somatic and germ-line DNA and epigenetics are reported to play large roles in accelerating the onset of human diseases. Cellular mechanisms of aging and age-related diseases are not completely understood. However, recent discoveries in molecular biology have revealed that microRNAs (miRNAs) are potential indicators of aging, cellular senescence, and Alzheimer's disease (AD). The purpose of our chapter is to highlight recent advancements in miRNAs and their involvement in cellular changes in aging, cellular senescence, and AD. This chapter also critically evaluates miRNA-based therapeutic drug targets for aging and age-related diseases, particularly Alzheimer's.

Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages127-171
Number of pages45
DOIs
StatePublished - 2017

Publication series

NameProgress in Molecular Biology and Translational Science
Volume146
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Keywords

  • Alzheimer's disease
  • MicroRNAs
  • Mitochondrial dysfunction
  • Phosphorylated tau
  • Synaptic damage

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    Reddy, P. H., Williams, J., Smith, F., Bhatti, J. S., Kumar, S., Vijayan, M., Kandimalla, R., Kuruva, C. S., Wang, R., Manczak, M., Yin, X., & Reddy, A. P. (2017). MicroRNAs, Aging, Cellular Senescence, and Alzheimer's Disease. In Progress in Molecular Biology and Translational Science (pp. 127-171). (Progress in Molecular Biology and Translational Science; Vol. 146). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2016.12.009