MicroRNA: A new player in stem cells

Baohong Zhang, Xiaoping Pan, Todd A. Anderson

Research output: Contribution to journalShort surveypeer-review

101 Scopus citations

Abstract

microRNAs (miRNAs) are an abundant class of endogenous non-protein-coding small RNAs, which negatively regulate gene expression at the posttranscriptional level in many developmental and metabolic processes. miRNAs regulate a variety of biological processes, including developmental timing, signal transduction, tissue differentiation and maintenance, disease, and carcinogenesis. Emerging evidence demonstrates that miRNAs also play an essential role in stem cell self-renewal and differentiation. Some miRNAs are specifically expressed in stem cells, control stem cell self-renewal, and differentiation through negatively regulating the expression of certain key genes in stem cells.

Original languageEnglish
Pages (from-to)266-269
Number of pages4
JournalJournal of Cellular Physiology
Volume209
Issue number2
DOIs
StatePublished - Nov 2006

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