Microfluidics for sepsis early diagnosis and prognosis: A review of recent methods

Ye Zhang, Yun Zhou, Yijia Yang, Dimitri Pappas

Research output: Contribution to journalArticlepeer-review

Abstract

Sepsis is a complex disorder of immune system response to infections that can be caused by a wide range of clinical contexts. Traditional methods for sepsis detection include molecular diagnosis, biomarkers either based on protein concentration or cell surface expression, and microbiological cultures. Development of point-of-care (POC) instruments, which can provide high accuracy and consume less time, is in unprecedented demand. Within the past few years, applications of microfluidic systems for sepsis detection have achieved excellent performance. In this review, we discuss the most recent microfluidic applications specifically in sepsis detection, and propose their advantages and disadvantages. We also present a comprehensive review of other traditional and current sepsis diagnosis methods to obtain a general understanding of the present conditions, which can hopefully direct the development of a new sepsis roadmap.

Original languageEnglish
Pages (from-to)2110-2125
Number of pages16
JournalAnalyst
Volume146
Issue number7
DOIs
StatePublished - Apr 7 2021

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