Metal-free preparation of cycloalkyl aryl sulfides via di-tert-butyl peroxide-promoted oxidative C(sp3)-H bond thiolation of cycloalkanes

Jincan Zhao, Hong Fang, Jianlin Han, Yi Pan, Guigen Li

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64 Scopus citations

Abstract

A concise thiolation of the C(sp3)-H bond of cycloalkanes with diaryl disulfides in the presence of the oxidant di-tert-butyl peroxide (DTBP) has been developed. This reaction, without using any metal catalyst, tolerates varieties of disulfides and cycloalkanes substrates, giving good to excellent chemical yields, and thus provides a useful approach to cycloalkyl aryl sulfides from unactivated cycloalkanes.

Original languageEnglish
Pages (from-to)2719-2724
Number of pages6
JournalAdvanced Synthesis and Catalysis
Volume356
Issue number11-12
DOIs
StatePublished - Aug 11 2014

Keywords

  • cycloalkanes
  • metal-free conditions
  • oxidative process
  • thiolation

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