Metal-free C(sp(3))-H functionalization: oxidative carbo-oxygenation of alpha-diazo carbonyls via radical dediazotization

Nan-Nan Wang, Wen-Juan Hao, Tian-Shu Zhang, Guigen Li, Ya-Nan Wu, Shu-Jiang Tu, Bo Jiang

Research output: Contribution to journalArticle

Abstract

A novel three-component carbo-oxygenation of alpha-diazo carbonyls for flexible synthesis of unprecedented alpha-aminooxy-beta-amino ketones has been established through metal-free C(sp(3))-H functionalization from readily accessible N,N-dimethylanilines and N-hydroxyphthalimide. The reaction pathway involves an in situ-generated phthalimide N-oxyl radical-triggered dediazotization/radical coupling sequence, leading to C-O and C-C bond formation.
Original languageEnglish
Pages (from-to)5144-5147
JournalChemical Communications
StatePublished - 2016

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