Metal-free [3+2+1]/[2+2+1] biscyclization: Stereospecific construction with concomitant functionalization of indolizin-5(1 H)-one

Tuan Jie Li, Zhong Qiu Liu, Hong Mei Yin, Chang Sheng Yao, Bo Jiang, Xiang Shan Wang, Shu Jiang Tu, Xiu Ling Li, Guigen Li

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization strategy has been developed for the stereospecific construction with concomitant derivation of biologically significant indolizin-5(1H)-ones from simple and commercial starting materials. The transformations are notable because they can yield five new σ bonds and six stereocenters including a quaternary carbon center in a single operation.

Original languageEnglish
Pages (from-to)11414-11420
Number of pages7
JournalJournal of Organic Chemistry
Volume78
Issue number22
DOIs
StatePublished - Nov 15 2013

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