Metabolism of mevalonic acid to long chain fatty alcohols in an insect

W. David Nes; Bruce C. Campbell; Allan E. Stafford; William F. Haddon; Mabry Benson

doi:10.1016/0006-291X(82)92135-0

Metabolism of mevalonic acid to long chain fatty alcohols in an insect

W. David Nes, Bruce C. Campbell, Allan E. Stafford, William F. Haddon, Mabry Benson

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A mixture of long chain fatty alcohols (LCFA) with chain lengths of 24 to 30 carbon atoms, as free and esterified components, have been isolated from the aphid, Schizaphis graminum. Both radiolabelled mevalonic acid and palmitic acid served as effective precursors in the synthesis of LCFA. This is the first time that the trans-methylglutaconate shunt has been shown to be operational for fatty alcohol synthesis and to occur in a lower-evolved animal.

Original language	English
Pages (from-to)	1258-1263
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	108
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(82)92135-0
State	Published - Oct 15 1982

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AU - Benson, Mabry

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AB - A mixture of long chain fatty alcohols (LCFA) with chain lengths of 24 to 30 carbon atoms, as free and esterified components, have been isolated from the aphid, Schizaphis graminum. Both radiolabelled mevalonic acid and palmitic acid served as effective precursors in the synthesis of LCFA. This is the first time that the trans-methylglutaconate shunt has been shown to be operational for fatty alcohol synthesis and to occur in a lower-evolved animal.

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Metabolism of mevalonic acid to long chain fatty alcohols in an insect

Abstract

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