Metabolism of 2(RS),3-epiminosqualene to 24(RS),25-epiminolanosterol by Gibberella fujikuroi

W. David Nes, Edward J. Parish

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The metabolic fate of 2(RS),3-epiminosqualene (Isq.), a demonstrable inhibitor of the 2,3-oxidosqualene-lanosterol cyclase, has been studied in Gibberella fujikuroi. The fungus transforms Isq. to a tetracyclic product for which the 24(RS),25-epiminolanosterol (EL) formulation was indicated by chromatographic and spectral data. The results are consistent with the pathway: Isq.→2,3-imino-22, 23-oxidosqualene→EL.

Original languageEnglish
Pages (from-to)375-376
Number of pages2
JournalLipids
Volume23
Issue number4
DOIs
StatePublished - Apr 1988

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