Metabolism of 2(RS),3-epiminosqualene to 24(RS),25-epiminolanosterol by Gibberella fujikuroi

W. David Nes; Edward J. Parish

doi:10.1007/BF02537354

Metabolism of 2(RS),3-epiminosqualene to 24(RS),25-epiminolanosterol by Gibberella fujikuroi

W. David Nes, Edward J. Parish

Chemistry and Biochemistry

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2 Scopus citations

Abstract

The metabolic fate of 2(RS),3-epiminosqualene (Isq.), a demonstrable inhibitor of the 2,3-oxidosqualene-lanosterol cyclase, has been studied in Gibberella fujikuroi. The fungus transforms Isq. to a tetracyclic product for which the 24(RS),25-epiminolanosterol (EL) formulation was indicated by chromatographic and spectral data. The results are consistent with the pathway: Isq.→2,3-imino-22, 23-oxidosqualene→EL.

Original language	English
Pages (from-to)	375-376
Number of pages	2
Journal	Lipids
Volume	23
Issue number	4
DOIs	https://doi.org/10.1007/BF02537354
State	Published - Apr 1988

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title = "Metabolism of 2(RS),3-epiminosqualene to 24(RS),25-epiminolanosterol by Gibberella fujikuroi",

abstract = "The metabolic fate of 2(RS),3-epiminosqualene (Isq.), a demonstrable inhibitor of the 2,3-oxidosqualene-lanosterol cyclase, has been studied in Gibberella fujikuroi. The fungus transforms Isq. to a tetracyclic product for which the 24(RS),25-epiminolanosterol (EL) formulation was indicated by chromatographic and spectral data. The results are consistent with the pathway: Isq.→2,3-imino-22, 23-oxidosqualene→EL.",

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AU - Parish, Edward J.

PY - 1988/4

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N2 - The metabolic fate of 2(RS),3-epiminosqualene (Isq.), a demonstrable inhibitor of the 2,3-oxidosqualene-lanosterol cyclase, has been studied in Gibberella fujikuroi. The fungus transforms Isq. to a tetracyclic product for which the 24(RS),25-epiminolanosterol (EL) formulation was indicated by chromatographic and spectral data. The results are consistent with the pathway: Isq.→2,3-imino-22, 23-oxidosqualene→EL.

AB - The metabolic fate of 2(RS),3-epiminosqualene (Isq.), a demonstrable inhibitor of the 2,3-oxidosqualene-lanosterol cyclase, has been studied in Gibberella fujikuroi. The fungus transforms Isq. to a tetracyclic product for which the 24(RS),25-epiminolanosterol (EL) formulation was indicated by chromatographic and spectral data. The results are consistent with the pathway: Isq.→2,3-imino-22, 23-oxidosqualene→EL.

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IS - 4

ER -

Metabolism of 2(RS),3-epiminosqualene to 24(RS),25-epiminolanosterol by Gibberella fujikuroi

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